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10.4168/aair.2015.7.5.421 http://scihub22266oqcxt.onion/10.4168/aair.2015.7.5.421 C4509654!4509654!26122502     free     free     free       Allergy+Asthma+Immunol+Res 2015 ; 7 (5): 421-30 Nephropedia Template TP {{tp|p=26122502|t=2015. Chronic Rhinosinusitis and the Coagulation System |pdf=|usr=}}{{26122502}} gab.com Text Chronic Rhinosinusitis and the Coagulation System JO: Allergy Asthma Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26122502 #FOAvip Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an etiologic role in many diseases, such as asthma and other inflammatory conditions. While studies on the relationship between asthma and dysregulated coagulation have been reported, the role of the coagulation system in the pathogenesis of CRS has only been considered following recent reports. Excessive fibrin deposition is seen in nasal polyp (NP) tissue from patients with chronic rhinosinusitis with nasal polyp (CRSwNP) and is associated with activation of thrombin, reduction of tissue plasminogen activator (t-PA) and upregulation of coagulation factor XIII-A (FXIII-A), all events that can contribute to fibrin deposition and crosslinking. These findings were reproduced in a murine model of NP that was recently established. Elucidation of the mechanisms of fibrin deposition may enhance our understanding of tissue remodeling in the pathophysiology of NP and provide new targets for the treatment of CRSwNP. Twit Text FOAVip Chronic Rhinosinusitis and the Coagulation System ????Allergy Asthma Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26122502 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26122502 #FOAvip English Wikipedia <ref>{{Cite pmid|26122502}}</ref> Chronic Rhinosinusitis and the Coagulation System #MMPMID26122502 Kim DY; Cho SH; Takabayashi T; Schleimer RP Allergy Asthma Immunol Res 2015[Sep]; 7 (5): 421-30 PMID26122502show ga Chronic rhinosinusitis (CRS) is one of the most common chronic diseases in adults and severely affects quality of life in patients. Although various etiologic and pathogenic mechanisms of CRS have been proposed, the causes of CRS remain uncertain. Abnormalities in the coagulation cascade may play an etiologic role in many diseases, such as asthma and other inflammatory conditions. While studies on the relationship between asthma and dysregulated coagulation have been reported, the role of the coagulation system in the pathogenesis of CRS has only been considered following recent reports. Excessive fibrin deposition is seen in nasal polyp (NP) tissue from patients with chronic rhinosinusitis with nasal polyp (CRSwNP) and is associated with activation of thrombin, reduction of tissue plasminogen activator (t-PA) and upregulation of coagulation factor XIII-A (FXIII-A), all events that can contribute to fibrin deposition and crosslinking. These findings were reproduced in a murine model of NP that was recently established. Elucidation of the mechanisms of fibrin deposition may enhance our understanding of tissue remodeling in the pathophysiology of NP and provide new targets for the treatment of CRSwNP. äChronic Rhinosinusitis and the Coagulation System (epmc).pdf DeepDyve Pubget Overpricing