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10.4049/jimmunol.1302766 http://scihub22266oqcxt.onion/10.4049/jimmunol.1302766 C4509623!4509623!24659691     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2014 ; 192 (8): 3569-81 Nephropedia Template TP {{tp|p=24659691|t=2014. Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma |pdf=|usr=}}{{24659691}} gab.com Text Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24659691 #FOAvip Viruses utilize Tyro3, Axl, and Mertk (TAM) receptor tyrosine kinases to infect and modulate the immune properties of various cell types leading us to investigate whether TAM receptor activation impacted primary viral infection and viral exacerbation of asthma in experimental models. In these lung-specific models, we observed that Axl was the most abundantly induced TAM receptor protein. During primary respiratory syncytial virus (RSV) infection, anti-Axl mAb treatment significantly increased the number of IFN-?-producing T cells and NK cells, and significantly suppressed RSV replication and whole lung levels of IL-4 and IL-13. Intrapulmonary H1N1 infection induced lethal pulmonary inflammation but anti-Axl mAb treatment of infected mice significantly increased the number of IFN-?-producing macrophages and dendritic cells, and significantly suppressed neutrophil infiltration. Consequently, the lethal effect of H1N1 infection in this model was significantly reduced in the mAb-treated group compared with the IgG control-treated group. Targeting Axl also inhibited airway hyperresponsiveness, IL-4 and IL-13 production, and goblet cell metaplasia in an Aspergillus fumigatus-induced asthma model. Finally, infection of mice with RSV during fungal asthma significantly exacerbated airway inflammation, goblet cell metaplasia, and airway remodeling but all of these features in this viral exacerbation model were ameliorated by anti-Axl mAb treatment. Together, these results demonstrate that Axl modulates the pulmonary immune response during viral and/or allergic pathology, and also suggest that targeting this TAM receptor might provide a novel therapeutic approach in these infectious diseases. Twit Text FOAVip Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24659691 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24659691 #FOAvip English Wikipedia <ref>{{Cite pmid|24659691}}</ref> Axl receptor blockade ameliorates pulmonary pathology resulting from primary viral infection and viral exacerbation of asthma #MMPMID24659691 Shibata T; Habiel DM; Coelho AL; Kunkel SL; Lukacs NW; Hogaboam CM J Immunol 2014[Apr]; 192 (8): 3569-81 PMID24659691show ga Viruses utilize Tyro3, Axl, and Mertk (TAM) receptor tyrosine kinases to infect and modulate the immune properties of various cell types leading us to investigate whether TAM receptor activation impacted primary viral infection and viral exacerbation of asthma in experimental models. In these lung-specific models, we observed that Axl was the most abundantly induced TAM receptor protein. During primary respiratory syncytial virus (RSV) infection, anti-Axl mAb treatment significantly increased the number of IFN-?-producing T cells and NK cells, and significantly suppressed RSV replication and whole lung levels of IL-4 and IL-13. Intrapulmonary H1N1 infection induced lethal pulmonary inflammation but anti-Axl mAb treatment of infected mice significantly increased the number of IFN-?-producing macrophages and dendritic cells, and significantly suppressed neutrophil infiltration. Consequently, the lethal effect of H1N1 infection in this model was significantly reduced in the mAb-treated group compared with the IgG control-treated group. Targeting Axl also inhibited airway hyperresponsiveness, IL-4 and IL-13 production, and goblet cell metaplasia in an Aspergillus fumigatus-induced asthma model. Finally, infection of mice with RSV during fungal asthma significantly exacerbated airway inflammation, goblet cell metaplasia, and airway remodeling but all of these features in this viral exacerbation model were ameliorated by anti-Axl mAb treatment. Together, these results demonstrate that Axl modulates the pulmonary immune response during viral and/or allergic pathology, and also suggest that targeting this TAM receptor might provide a novel therapeutic approach in these infectious diseases. äAxl receptor blockade ameliorates pulmonary pathology resulting from p(epmc).pdf DeepDyve Pubget Overpricing