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10.3892/ol.2015.3287 http://scihub22266oqcxt.onion/10.3892/ol.2015.3287 C4509456!4509456!26622610     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2015 ; 10 (2): 985-9 Nephropedia Template TP {{tp|p=26622610|t=2015. RhoC is essential in TGF-?1 induced epithelial-mesenchymal transition in cervical cancer cells |pdf=|usr=}}{{26622610}} gab.com Text RhoC is essential in TGF- 1 induced epithelial-mesenchymal transition in cervical cancer cells JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26622610 #FOAvip Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-?1 induced EMT. EMT occurred in human cervical carcinoma SiHa cells following TGF-?1 stimulation for 4 days, as demonstrated by the appearance of mesenchymal morphology, reorganization of the actin cytoskeleton, reduced E-cadherin expression and increased Vimentin expression, which was associated with increased RhoC expression and activity. However, EMT was not observed in cells that were pretreated with RhoC siRNA prior to TGF-?1 stimulation. Downregulation of RhoC 4 days following TGF-?1 stimulation was not able to reverse the existing EMT. In addition, TGF-?1 promoted the invasion of the control SiHa cells but not that of the cells in which RhoC was downregulated. In conclusion, RhoC expression is activated by TGF-?1, and sufficient RhoC expression levels are essential for TGF-?1-induced EMT. Twit Text FOAVip RhoC is essential in TGF- 1 induced epithelial-mesenchymal transition in cervical cancer cells ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=26622610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26622610 #FOAvip English Wikipedia <ref>{{Cite pmid|26622610}}</ref> RhoC is essential in TGF-?1 induced epithelial-mesenchymal transition in cervical cancer cells #MMPMID26622610 HE X; QIAN Y; CAI H; YANG S; CAI J; WANG Z Oncol Lett 2015[Aug]; 10 (2): 985-9 PMID26622610show ga Epithelial-mesenchymal transition (EMT) is a critical process in the promotion of epithelial tumor progression and metastasis. The present study aimed to investigate the role of Ras homolog gene family, member C (RhoC) guanosine triphosphatase (GTPase) in transforming growth factor (TGF)-?1 induced EMT. EMT occurred in human cervical carcinoma SiHa cells following TGF-?1 stimulation for 4 days, as demonstrated by the appearance of mesenchymal morphology, reorganization of the actin cytoskeleton, reduced E-cadherin expression and increased Vimentin expression, which was associated with increased RhoC expression and activity. However, EMT was not observed in cells that were pretreated with RhoC siRNA prior to TGF-?1 stimulation. Downregulation of RhoC 4 days following TGF-?1 stimulation was not able to reverse the existing EMT. In addition, TGF-?1 promoted the invasion of the control SiHa cells but not that of the cells in which RhoC was downregulated. In conclusion, RhoC expression is activated by TGF-?1, and sufficient RhoC expression levels are essential for TGF-?1-induced EMT. äRhoC is essential in TGF-?1 induced epithelial-mesenchymal transition (epmc).pdf DeepDyve Pubget Overpricing