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10.1080/15548627.2015.1048173 http://scihub22266oqcxt.onion/10.1080/15548627.2015.1048173 C4509437!4509437!26020424     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Autophagy 2015 ; 11 (5): 854-5 Nephropedia Template TP {{tp|p=26020424|t=2015. Blocking tumor growth by targeting autophagy and SQSTM1 in vivo |pdf=|usr=}}{{26020424}} gab.com Text Blocking tumor growth by targeting autophagy and SQSTM1 in vivo JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26020424 #FOAvip Autophagy is a highly conserved cellular process for degradation of bulk cytoplasmic materials in response to starvation and maintenance of cellular homeostasis. Dysfunction of autophagy is implicated in a variety of diseases including cancer. In a recent study, we devised a system for inducible deletion of an essential autophagy gene Rb1cc1/Fip200 in established tumor cells in vivo and showed that Rb1cc1 is required for maintaining tumor growth. We further investigated the role of the accumulated SQSTM1 in Rb1cc1-null autophagy-deficient tumor cells. To our surprise, the increased SQSTM1 was not responsible for the inhibition of tumor growth, but rather supported the residual growth of tumors (i.e., partially compensated for the defective growth caused by Rb1cc1 deletion). Further analysis indicated that SQSTM1 promoted tumor growth in autophagy-deficient cells at least partially through its activation of the NFKB signaling pathway. A working model is proposed to account for our findings, which suggest that targeting both autophagy and the consequently increased SQSTM1 may be exploited for developing more effective cancer therapies. Twit Text FOAVip Blocking tumor growth by targeting autophagy and SQSTM1 in vivo ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=26020424 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26020424 #FOAvip English Wikipedia <ref>{{Cite pmid|26020424}}</ref> Blocking tumor growth by targeting autophagy and SQSTM1 in vivo #MMPMID26020424 Wei H; Guan JL Autophagy 2015[May]; 11 (5): 854-5 PMID26020424show ga Autophagy is a highly conserved cellular process for degradation of bulk cytoplasmic materials in response to starvation and maintenance of cellular homeostasis. Dysfunction of autophagy is implicated in a variety of diseases including cancer. In a recent study, we devised a system for inducible deletion of an essential autophagy gene Rb1cc1/Fip200 in established tumor cells in vivo and showed that Rb1cc1 is required for maintaining tumor growth. We further investigated the role of the accumulated SQSTM1 in Rb1cc1-null autophagy-deficient tumor cells. To our surprise, the increased SQSTM1 was not responsible for the inhibition of tumor growth, but rather supported the residual growth of tumors (i.e., partially compensated for the defective growth caused by Rb1cc1 deletion). Further analysis indicated that SQSTM1 promoted tumor growth in autophagy-deficient cells at least partially through its activation of the NFKB signaling pathway. A working model is proposed to account for our findings, which suggest that targeting both autophagy and the consequently increased SQSTM1 may be exploited for developing more effective cancer therapies. äBlocking tumor growth by targeting autophagy and SQSTM1 in vivo (epmc).pdf DeepDyve Pubget Overpricing