Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26221266
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Clin+Exp+Med
2015 ; 8
(5
): 7270-8
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Clinical efficacy of spironolactone for resistant hypertension: a meta analysis
from randomized controlled clinical trials
#MMPMID26221266
Guo H
; Xiao Q
Int J Clin Exp Med
2015[]; 8
(5
): 7270-8
PMID26221266
show ga
OBJECTIVES: This study sought to determine the current effectiveness and safety
of spironolactone for resistant hypertension. METHODS: Pubmed, EMBASE and
Cochrane databases were searched to identify studies that used spironolactone as
add-on treatment in resistant hypertension patients. The major outcome is
reduction of blood pressure. RESULTS: Three randomized controlled trials, 5
observational study without control group have been identified. At follow-up
review, there was a reduction in mean systolic and diastolic blood pressure (BP)
respectively, of -20.56 mmHg (95% confidence interval [CI]: -36.47 to -4.65 mmHg)
and -6.04 mm Hg (95% CI: -10.24 to -1.85 mm Hg) in controlled study. In
uncontrolled studies, at 6-month follow-up, systolic and diastolic BP were
reduced -20.73 mm Hg (95% CI: -25.62 to -15.83 mm Hg) and -8.94 mm Hg (95% CI:
-10.82 to -7.05 mm Hg, respectively. CONCLUSION: Spironolactone resulted in the
reduction of mean BP in patients with resistant hypertension. The sustained
efficacy and safety of spironolactone need to further confirm by large randomized
controlled trials with long-term follow-up.