Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12872-015-0051-z http://scihub22266oqcxt.onion/10.1186/s12872-015-0051-z C4508806!4508806!26195004     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       BMC+Cardiovasc+Disord 2015 ; 15 (ä): ä Nephropedia Template TP {{tp|p=26195004|t=2015. Troponin in diabetic patients with and without chronic coronary artery disease |pdf=|usr=}}{{26195004}} gab.com Text Troponin in diabetic patients with and without chronic coronary artery disease JO: BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=26195004 #FOAvip Background: Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary artery disease have different levels of troponin compared with diabetic patients with normal coronary arteries. To investigate this question, we determined the concentrations of a level 1 troponin assay in two groups of diabetic patients: those with multivessel coronary artery disease and those with angiographically normal coronary arteries. Methods: We studied 95 diabetic patients and compared troponin in serum samples from 50 patients with coronary artery disease (mean age?=?63.7, 58 % male) with 45 controls with angiographically normal coronary arteries. Brain natriuretic peptide and the oxidative stress biomarkers myeloperoxidase, nitrotyrosine and oxidized LDL were also determined. Results: Diabetic patients with coronary artery disease had higher levels of troponin than did controls (median values, 12.0 pg/mL (95 % CI:10?16) vs 7.0 pg/mL (95 % CI: 5.9-8.5), respectively; p?=?0.0001). The area under the ROC curve for the diagnosis of CAD was 0.712 with a sensitivity of 70 % and a specificity of 66 %. Plasma BNP levels and oxidative stress variables (myeloperoxidase, nitrotyrosine, and oxidized LDL) were not different between the two groups. In a multivariate analysis, gender (p?=?0.04), serum glucose (0.03) and Troponin I (p?=?0.01) had independent statistical significance. Conclusion: Troponin elevation is related to the presence of chronic coronary artery disease in diabetic patients with multiple associated cardiovascular risk factors. Troponin may serve as a biomarker in this high-risk population. Trial registration: http://www.controlled-trials.com Registration number:ISRCTN26970041 Twit Text FOAVip Troponin in diabetic patients with and without chronic coronary artery disease ????BMC Cardiovasc Disord http://www.kidney.de/pget.php?&tw=1&pmid=26195004 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26195004 #FOAvip English Wikipedia <ref>{{Cite pmid|26195004}}</ref> Troponin in diabetic patients with and without chronic coronary artery disease #MMPMID26195004 Segre CAW; Hueb W; Garcia RMR; Rezende PC; Favarato D; Strunz CMC; Sprandel Mda CO; Roggério A; Carvalho ALde O; Maranhão RC; Ramires JAF; Filho RK BMC Cardiovasc Disord 2015[]; 15 (ä): ä PMID26195004show ga Background: Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary artery disease have different levels of troponin compared with diabetic patients with normal coronary arteries. To investigate this question, we determined the concentrations of a level 1 troponin assay in two groups of diabetic patients: those with multivessel coronary artery disease and those with angiographically normal coronary arteries. Methods: We studied 95 diabetic patients and compared troponin in serum samples from 50 patients with coronary artery disease (mean age?=?63.7, 58 % male) with 45 controls with angiographically normal coronary arteries. Brain natriuretic peptide and the oxidative stress biomarkers myeloperoxidase, nitrotyrosine and oxidized LDL were also determined. Results: Diabetic patients with coronary artery disease had higher levels of troponin than did controls (median values, 12.0 pg/mL (95 % CI:10?16) vs 7.0 pg/mL (95 % CI: 5.9-8.5), respectively; p?=?0.0001). The area under the ROC curve for the diagnosis of CAD was 0.712 with a sensitivity of 70 % and a specificity of 66 %. Plasma BNP levels and oxidative stress variables (myeloperoxidase, nitrotyrosine, and oxidized LDL) were not different between the two groups. In a multivariate analysis, gender (p?=?0.04), serum glucose (0.03) and Troponin I (p?=?0.01) had independent statistical significance. Conclusion: Troponin elevation is related to the presence of chronic coronary artery disease in diabetic patients with multiple associated cardiovascular risk factors. Troponin may serve as a biomarker in this high-risk population. Trial registration: http://www.controlled-trials.com Registration number:ISRCTN26970041 äTroponin in diabetic patients with and without chronic coronary artery(epmc).pdf DeepDyve Pubget Overpricing