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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Pathol+Transl+Med
2015 ; 49
(4
): 325-30
Nephropedia Template TP
gab.com Text
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English Wikipedia
WHO Grade IV Gliofibroma: A Grading Label Denoting Malignancy for an Otherwise
Commonly Misinterpreted Neoplasm
#MMPMID26081826
Escalante Abril PA
; Salazar MF
; López García NL
; Madrazo Moya MN
; Zamora Guerra YU
; Mata Mendoza YG
; Gómez Apo E
; Chávez Macías LG
J Pathol Transl Med
2015[Jul]; 49
(4
): 325-30
PMID26081826
show ga
We report a 50-year-old woman with no relevant clinical history who presented
with headache and loss of memory. Magnetic resonance imaging showed a left
parieto-temporal mass with annular enhancement after contrast media
administration, rendering a radiological diagnosis of high-grade astrocytic
neoplasm. Tumour sampling was performed but the patient ultimately died as a
result of disease. Microscopically, the lesion had areas of glioblastoma mixed
with a benign mesenchymal constituent; the former showed hypercellularity,
endothelial proliferation, high mitotic activity and necrosis, while the latter
showed fascicles of long spindle cells surrounded by collagen and reticulin
fibers. With approximately 40 previously reported cases, gliofibroma is a rare
neoplasm defined as either glio-desmoplastic or glial/benign mesenchymal. As
shown in our case, its prognosis is apparently determined by the degree of
anaplasia of the glial component.