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10.1111/jcmm.12263 http://scihub22266oqcxt.onion/10.1111/jcmm.12263 C4508156!4508156!24629065     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Mol+Med 2014 ; 18 (6): 1172-83 Nephropedia Template TP {{tp|p=24629065|t=2014. Transforming growth factor-?1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo |pdf=|usr=}}{{24629065}} gab.com Text Transforming growth factor- 1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo JO: J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=24629065 #FOAvip Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxia but is also involved in pathophysiologies such as tumour growth and retinopathies. Understanding the molecular mechanisms involved is important to design strategies for therapeutic intervention. One important regulator of angiogenesis is transforming growth factor-?1 (TGF-?1). In addition, reactive oxygen species (ROS) and the ROS-forming NADPH oxidase type 4 (Nox4) have been implicated as additional regulators such as during hypoxia. Here, we show that both processes are indeed mechanistically linked. TGF-?1-stimulated Nox4 expression and ROS formation in endothelial cells. In cells from Nox4-deficient mice, TGF-?1-induced cell proliferation, migration and tube formation were abolished. In vivo, TGF-?1 stimulated growth of blood vessels into sponges implanted subcutaneously, and this angiogenesis was markedly reduced in Nox4 knockout mice. Thus, endothelial cells are regulated by a TGF-?1 signalling pathway involving Nox4-derived ROS to promote angiogenesis. In order to abrogate pathological angiogenesis triggered by a multitude of factors, such as TGF-?1 and hypoxia, Nox4 may thus be an ideal therapeutic target. Twit Text FOAVip Transforming growth factor- 1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo ????J Cell Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=24629065 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24629065 #FOAvip English Wikipedia <ref>{{Cite pmid|24629065}}</ref> Transforming growth factor-?1 requires NADPH oxidase 4 for angiogenesis in vitro and in vivo #MMPMID24629065 Peshavariya HM; Chan EC; Liu GS; Jiang F; Dusting GJ J Cell Mol Med 2014[Jun]; 18 (6): 1172-83 PMID24629065show ga Angiogenesis, the formation of new blood vessels, is a key physiological event in organ development and tissue responses to hypoxia but is also involved in pathophysiologies such as tumour growth and retinopathies. Understanding the molecular mechanisms involved is important to design strategies for therapeutic intervention. One important regulator of angiogenesis is transforming growth factor-?1 (TGF-?1). In addition, reactive oxygen species (ROS) and the ROS-forming NADPH oxidase type 4 (Nox4) have been implicated as additional regulators such as during hypoxia. Here, we show that both processes are indeed mechanistically linked. TGF-?1-stimulated Nox4 expression and ROS formation in endothelial cells. In cells from Nox4-deficient mice, TGF-?1-induced cell proliferation, migration and tube formation were abolished. In vivo, TGF-?1 stimulated growth of blood vessels into sponges implanted subcutaneously, and this angiogenesis was markedly reduced in Nox4 knockout mice. Thus, endothelial cells are regulated by a TGF-?1 signalling pathway involving Nox4-derived ROS to promote angiogenesis. In order to abrogate pathological angiogenesis triggered by a multitude of factors, such as TGF-?1 and hypoxia, Nox4 may thus be an ideal therapeutic target. äTransforming growth factor-?1 requires NADPH oxidase 4 for angiogenesi(epmc).pdf DeepDyve Pubget Overpricing