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Severe thrombocytopenia in a child secondary to passive platelet antibody
transfer from a plasma transfusion
#MMPMID23459377
Collins CL
; Scott JP
; Panepinto JA
; Punzalan RC
J Pediatr Hematol Oncol
2013[Jul]; 35
(5
): e226-8
PMID23459377
show ga
Although rare, passive transfer of platelet antibodies through blood products can
result in thrombocytopenia, acute transfusion reactions, and death. We report a
case of severe alloimmune thrombocytopenia from a plasma transfusion. A postliver
transplant patient with a normal platelet count received fresh frozen plasma
before liver biopsy. Postbiopsy, she developed cardiorespiratory distress,
petechiae, and severe thrombocytopenia (platelet count 2000/?L). Her platelet
count recovered to normal after 1 week. This diagnosis should be considered
whenever an unexpected drop in the platelet count occurs after a plasma-rich
transfusion. Conservative transfusion practices and more targeted donor screening
may prevent similar events.