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2015 ; 10
(7
): e0130977
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Salivirus in Children and Its Association with Childhood Acute Gastroenteritis: A
Paired Case-Control Study
#MMPMID26193371
Yu JM
; Ao YY
; Liu N
; Li LL
; Duan ZJ
PLoS One
2015[]; 10
(7
): e0130977
PMID26193371
show ga
Salivirus was recently discovered in children with gastroenteritis and in sewage.
Though a causative role for salivirus in childhood gastroenteritis was suggested
in the previous study, the relationship between salivirus and acute
gastroenteritis has not yet been clearly clarified. The sewage strain reported by
Ng, although represented by incomplete genome sequencing data, was distinct from
previously reported saliviruses, and had not previously been detected in humans.
A case-control study examining 461 paired stool samples from children with
diarrhea and healthy controls (1:1) was conducted in this study. Also, common
diarrheal viruses were detected and complete genome of a salivirus was
determined. Results showed that salivirus was detected in 16 (3.5%) and 13 (2.8%)
of the case and control samples, respectively; no differences in detection rates
(p=0.571) or mean values of viral loads (p=0.400) were observed between the
groups. Multivariate Cox regression revealed no association between salivirus and
gastroenteritis (p=0.774). The data also demonstrated that salivirus infection
did not exacerbate clinical symptoms of gastroenteritis in children. Furthermore,
complete genome sequence of a salivirus recovered from the feces of a child with
diarrhea (i.e., SaliV-FHB) shared a 99% nucleotide identity with the sewage
strain. In conclusion, a paired case-control study did not support a causative
role for salivirus strains detected in this study with pediatric gastroenteritis.
This study also demonstrated that all known saliviruses can be detected in the
feces of children with or without gastroenteritis.