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10.3390/s150612872 http://scihub22266oqcxt.onion/10.3390/s150612872 C4507685!4507685!26043176     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sensors+(Basel) 2015 ; 15 (6): 12872-83 Nephropedia Template TP {{tp|p=26043176|t=2015. Quantum Dot-Based Molecular Beacon to Monitor Intracellular MicroRNAs |pdf=|usr=}}{{26043176}} gab.com Text Quantum Dot-Based Molecular Beacon to Monitor Intracellular MicroRNAs JO: Sensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26043176 #FOAvip Fluorescence monitoring of endogenous microRNA (miRNA or miR) activity related to neuronal development using nano-sized materials provides crucial information on miRNA expression patterns in a noninvasive manner. In this study, we report a new method to monitor intracellular miRNA124a using quantum dot-based molecular beacon (R9-QD-miR124a beacon). The R9-QD-miR124a beacon was constructed using QDs and two probes, miR124a-targeting oligomer and arginine rich cell-penetrating peptide (R9 peptide). The miR124a-targeting oligomer contains a miR124a binging sequence and a black hole quencher 1 (BHQ1). In the absence of target miR124a, the R9-QD-miR124a beacon forms a partial duplex beacon and remained in quenched state because the BHQ1 quenches the fluorescence signal of the R9-QD-miR124a beacon. The binding of miR124a to the miR124a binding sequence of the miR124a-targeting oligomer triggered the separation of the BHQ1 quencher and subsequent signal-on of a red fluorescence signal. Moreover, enhanced cellular uptake was achieved by conjugation with the R9 peptide, which resulted in increased fluorescent signal of the R9-QD-miR124a beacons in P19 cells during neurogenesis due to the endogenous expression of miR124a. Twit Text FOAVip Quantum Dot-Based Molecular Beacon to Monitor Intracellular MicroRNAs ????Sensors (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=26043176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26043176 #FOAvip English Wikipedia <ref>{{Cite pmid|26043176}}</ref> Quantum Dot-Based Molecular Beacon to Monitor Intracellular MicroRNAs #MMPMID26043176 Lee J; Moon SU; Lee YS; Ali BA; Al-Khedhairy AA; Ali D; Ahmed J; Al Salem AM; Kim S Sensors (Basel) 2015[Jun]; 15 (6): 12872-83 PMID26043176show ga Fluorescence monitoring of endogenous microRNA (miRNA or miR) activity related to neuronal development using nano-sized materials provides crucial information on miRNA expression patterns in a noninvasive manner. In this study, we report a new method to monitor intracellular miRNA124a using quantum dot-based molecular beacon (R9-QD-miR124a beacon). The R9-QD-miR124a beacon was constructed using QDs and two probes, miR124a-targeting oligomer and arginine rich cell-penetrating peptide (R9 peptide). The miR124a-targeting oligomer contains a miR124a binging sequence and a black hole quencher 1 (BHQ1). In the absence of target miR124a, the R9-QD-miR124a beacon forms a partial duplex beacon and remained in quenched state because the BHQ1 quenches the fluorescence signal of the R9-QD-miR124a beacon. The binding of miR124a to the miR124a binding sequence of the miR124a-targeting oligomer triggered the separation of the BHQ1 quencher and subsequent signal-on of a red fluorescence signal. Moreover, enhanced cellular uptake was achieved by conjugation with the R9 peptide, which resulted in increased fluorescent signal of the R9-QD-miR124a beacons in P19 cells during neurogenesis due to the endogenous expression of miR124a. äQuantum Dot-Based Molecular Beacon to Monitor Intracellular MicroRNAs (epmc).pdf DeepDyve Pubget Overpricing