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10.1038/srep12255 http://scihub22266oqcxt.onion/10.1038/srep12255 C4507466!4507466 !26193241     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26193241 &cmd=llinks): Failed to open stream: HTTP request failed! 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Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth |pdf=|usr=}}{{26193241 }} gab.com Text Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26193241 #FOAvip Our previous studies found that B16-F10 melanoma growth in the rear footpad of immunocompetent mice induces marked B cell accumulation within tumor-draining popliteal lymph nodes (TDLN). This B cell accumulation drives TDLN remodeling that precedes and promotes metastasis, indicating a tumor-promoting role for TDLN B cells. Here we show that phenotypic characterization of lymphocytes in mice bearing B16-F10 melanomas identifies preferential accumulation of T2-MZP B cells in the TDLN. Comparison of non-draining LNs and spleens of tumor-bearing mice with LNs and spleens from naïve mice determined that this pattern of B cell accumulation was restricted to the TDLN. B cell-deficient and immunocompetent mice reconstituted with T2-MZP B cells but not with other B cell subsets displayed accelerated tumor growth, demonstrating that T2-MZP B cells possess regulatory activity in tumor-bearing mice. Unlike splenic regulatory B cells, however, these TDLN B cells did not exhibit increased IL-10 production, nor did they promote Treg generation in the TDLN. These findings demonstrate that tumors initially signal via the lymphatic drainage to stimulate the preferential accumulation of T2-MZP regulatory B cells. This local response may be an early and critical step in generating an immunosuppressive environment to permit tumor growth and metastasis. Twit Text FOAVip Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26193241 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26193241 #FOAvip English Wikipedia <ref>{{Cite pmid|26193241 }}</ref> Regulatory B cells preferentially accumulate in tumor-draining lymph nodes and promote tumor growth #MMPMID26193241 Ganti SN ; Albershardt TC ; Iritani BM ; Ruddell A Sci Rep 2015[Jul]; 5 (ä): 12255 PMID26193241 show ga Our previous studies found that B16-F10 melanoma growth in the rear footpad of immunocompetent mice induces marked B cell accumulation within tumor-draining popliteal lymph nodes (TDLN). This B cell accumulation drives TDLN remodeling that precedes and promotes metastasis, indicating a tumor-promoting role for TDLN B cells. Here we show that phenotypic characterization of lymphocytes in mice bearing B16-F10 melanomas identifies preferential accumulation of T2-MZP B cells in the TDLN. Comparison of non-draining LNs and spleens of tumor-bearing mice with LNs and spleens from naïve mice determined that this pattern of B cell accumulation was restricted to the TDLN. B cell-deficient and immunocompetent mice reconstituted with T2-MZP B cells but not with other B cell subsets displayed accelerated tumor growth, demonstrating that T2-MZP B cells possess regulatory activity in tumor-bearing mice. Unlike splenic regulatory B cells, however, these TDLN B cells did not exhibit increased IL-10 production, nor did they promote Treg generation in the TDLN. These findings demonstrate that tumors initially signal via the lymphatic drainage to stimulate the preferential accumulation of T2-MZP regulatory B cells. This local response may be an early and critical step in generating an immunosuppressive environment to permit tumor growth and metastasis. |Adoptive Transfer [MESH] |Animals [MESH] |B-Lymphocytes, Regulatory/*immunology [MESH] |Cell Proliferation [MESH] |Female [MESH] |Lymph Nodes/*immunology [MESH] |Lymphocyte Subsets/immunology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Neoplasms/*immunology/*pathology [MESH]Regulatory B cells preferentially accumulate in tumor-draining lymph n(epmc).pdf DeepDyve Pubget Overpricing