Biomaterials for Bone Regenerative Engineering #MMPMID25846250
Yu X; Tang X; Gohil SV; Laurencin CT
Adv Healthc Mater 2015[Jun]; 4 (9): 1268-85 PMID25846250show ga
Strategies for bone tissue regeneration have been continuously evolving for the last 25 years since the introduction of the ?tissue engineering? concept. The convergence of the life, physical, and engineering sciences has brought in several advanced technologies available to tissue engineers and scientists. This resulted in the creation of a new multidisciplinary field termed as ?regenerative engineering?. In this article, the role of biomaterials in bone regenerative engineering is systematically reviewed to elucidate the new design criteria for the next generation of biomaterials for bone regenerative engineering. We highlight the exemplary design of biomaterials harnessing various materials characteristics towards successful bone defect repair and regeneration. In particular, we concentrate our attention on the attempts of incorporating advanced materials science, stem cell technologies, and developmental biology into biomaterials design to engineer and develop the next generation bone grafts.