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10.1111/ajt.12931 http://scihub22266oqcxt.onion/10.1111/ajt.12931 C4507420!4507420 !25387427     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25387427 &cmd=llinks): Failed to open stream: HTTP request failed! 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Bone marrow-derived hematopoietic stem and progenitor cells infiltrate allogeneic and syngeneic transplants |pdf=|usr=}}{{25387427 }} gab.com Text Bone marrow-derived hematopoietic stem and progenitor cells infiltrate allogeneic and syngeneic transplants JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25387427 #FOAvip Lineage (CD3e, CD11b, GR1, B220 and Ly-76) negative hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) infiltrate islet allografts within 24?h posttransplantation. In fact, lineage(negative) Sca-1(+) cKit(+) ("LSK") cells, a classic signature for HSCs, were also detected among these graft infiltrating cells. Lineage negative graft infiltrating cells are functionally multi-potential as determined by a standard competitive bone marrow transplant (BMT) assay. By 3 months post-BMT, both CD45.1 congenic, lineage negative HSCs/HPCs and classic "LSK" HSCs purified from islet allograft infiltrating cells, differentiate and repopulate multiple mature blood cell phenotypes in peripheral blood, lymph nodes, spleen, bone marrow and thymus of CD45.2 hosts. Interestingly, "LSK" HSCs also rapidly infiltrate syngeneic islet transplants as well as allogeneic cardiac transplants and sham surgery sites. It seems likely that an inflammatory response, not an adaptive immune response to allo-antigen, is responsible for the rapid infiltration of islet and cardiac transplants by biologically active HSCs/HPCs. The pattern of hematopoietic differentiation obtained from graft infiltrating HSCs/HPCs, cells that are recovered from inflammatory sites, as noted in the competitive BMT assay, is not precisely the same as that of intramedullary HSCs. This does not refute the obvious multi-lineage potential of graft infiltrating HSCs/HPCs. Twit Text FOAVip Bone marrow-derived hematopoietic stem and progenitor cells infiltrate allogeneic and syngeneic transplants ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=25387427 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25387427 #FOAvip English Wikipedia <ref>{{Cite pmid|25387427 }}</ref> Bone marrow-derived hematopoietic stem and progenitor cells infiltrate allogeneic and syngeneic transplants #MMPMID25387427 Fan Z ; Enjoji K ; Tigges JC ; Toxavidis V ; Tchipashivili V ; Gong W ; Strom TB ; Koulmanda M Am J Transplant 2014[Dec]; 14 (12 ): 2869-73 PMID25387427 show ga Lineage (CD3e, CD11b, GR1, B220 and Ly-76) negative hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) infiltrate islet allografts within 24?h posttransplantation. In fact, lineage(negative) Sca-1(+) cKit(+) ("LSK") cells, a classic signature for HSCs, were also detected among these graft infiltrating cells. Lineage negative graft infiltrating cells are functionally multi-potential as determined by a standard competitive bone marrow transplant (BMT) assay. By 3 months post-BMT, both CD45.1 congenic, lineage negative HSCs/HPCs and classic "LSK" HSCs purified from islet allograft infiltrating cells, differentiate and repopulate multiple mature blood cell phenotypes in peripheral blood, lymph nodes, spleen, bone marrow and thymus of CD45.2 hosts. Interestingly, "LSK" HSCs also rapidly infiltrate syngeneic islet transplants as well as allogeneic cardiac transplants and sham surgery sites. It seems likely that an inflammatory response, not an adaptive immune response to allo-antigen, is responsible for the rapid infiltration of islet and cardiac transplants by biologically active HSCs/HPCs. The pattern of hematopoietic differentiation obtained from graft infiltrating HSCs/HPCs, cells that are recovered from inflammatory sites, as noted in the competitive BMT assay, is not precisely the same as that of intramedullary HSCs. This does not refute the obvious multi-lineage potential of graft infiltrating HSCs/HPCs. |*Bone Marrow Transplantation [MESH] |*Cell Lineage [MESH] |*Heart Transplantation [MESH] |*Islets of Langerhans Transplantation [MESH] |Animals [MESH] |Bone Marrow/*immunology [MESH] |Cell Differentiation [MESH] |Flow Cytometry [MESH] |Hematopoietic Stem Cells/cytology/*immunology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Inbred DBA [MESH] |Stem Cells/cytology/*immunology [MESH] |Transplantation, Homologous [MESH]Bone marrow-derived hematopoietic stem and progenitor cells infiltrate(epmc).pdf DeepDyve Pubget Overpricing