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10.1126/scisignal.2001811 http://scihub22266oqcxt.onion/10.1126/scisignal.2001811 C4507414!4507414!21900205     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2011 ; 4 (189): ra57 Nephropedia Template TP {{tp|p=21900205|t=2011. Small Molecule?Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease |pdf=|usr=}}{{21900205}} gab.com Text Small Molecule Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=21900205 #FOAvip The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the ?M (CD11b) and ?2 (CD18) subunits, is critical for leukocyte adhesion and migration and for immune functions. Blocking integrin-mediated leukocyte adhesion, although beneficial in experimental models, has had limited success in treating inflammatory diseases in humans. Here, we used an alternative strategy of inhibiting leukocyte recruitment by activating CD11b/CD18 with small-molecule agonists, which we term leukadherins. These compounds increased the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which resulted in decreased chemotaxis and transendothelial migration. Leukadherins also decreased leukocyte recruitment and reduced arterial narrowing after injury in rats. Moreover, compared to a known integrin antagonist, leukadherins better preserved kidney function in a mouse model of experimental nephritis. Leukadherins inhibited leukocyte recruitment by increasing leukocyte adhesion to the inflamed endothelium, which was reversed with a blocking antibody. Thus, we propose that pharmacological activation of CD11b/CD18 offers an alternative therapeutic approach for inflammatory diseases. Twit Text FOAVip Small Molecule Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=21900205 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=21900205 #FOAvip English Wikipedia <ref>{{Cite pmid|21900205}}</ref> Small Molecule?Mediated Activation of the Integrin CD11b/CD18 Reduces Inflammatory Disease #MMPMID21900205 Maiguel D; Faridi MH; Wei C; Kuwano Y; Balla KM; Hernandez D; Barth CJ; Lugo G; Donnelly M; Nayer A; Moita LF; Schürer S; Traver D; Ruiz P; Vazquez-Padron RI; Ley K; Reiser J; Gupta V Sci Signal 2011[Sep]; 4 (189): ra57 PMID21900205show ga The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the ?M (CD11b) and ?2 (CD18) subunits, is critical for leukocyte adhesion and migration and for immune functions. Blocking integrin-mediated leukocyte adhesion, although beneficial in experimental models, has had limited success in treating inflammatory diseases in humans. Here, we used an alternative strategy of inhibiting leukocyte recruitment by activating CD11b/CD18 with small-molecule agonists, which we term leukadherins. These compounds increased the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils, which resulted in decreased chemotaxis and transendothelial migration. Leukadherins also decreased leukocyte recruitment and reduced arterial narrowing after injury in rats. Moreover, compared to a known integrin antagonist, leukadherins better preserved kidney function in a mouse model of experimental nephritis. Leukadherins inhibited leukocyte recruitment by increasing leukocyte adhesion to the inflamed endothelium, which was reversed with a blocking antibody. Thus, we propose that pharmacological activation of CD11b/CD18 offers an alternative therapeutic approach for inflammatory diseases. äSmall Molecule?Mediated Activation of the Integrin CD11b/CD18 Reduces (epmc).pdf DeepDyve Pubget Overpricing