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10.4161/mco.29904 http://scihub22266oqcxt.onion/10.4161/mco.29904 C4507279!4507279!26203462     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cell+Oncol 2014 ; 1 (1): ä Nephropedia Template TP {{tp|p=26203462|t=2014. Chromosomal rearrangements in cancer: Detection and potential causal mechanisms |pdf=|usr=}}{{26203462}} gab.com Text Chromosomal rearrangements in cancer: Detection and potential causal mechanisms JO: Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26203462 #FOAvip Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple, involving a single balanced fusion that preserves the proper complement of genetic information, or complex with one or more fusions that disrupt this balance. Recent technological advances have improved our ability to detect and understand these rearrangements, leading to speculation about potential causal mechanisms such as defective DNA double strand break repair and faulty DNA replication. A better understanding of these potential cancer-causing mechanisms will lead to novel therapeutic regimens to fight cancer. This review describes technological advances in methods used to detect simple and complex chromosomal rearrangements, cancers that exhibit these rearrangements, potential mechanisms for rearrangement of chromosomes, and intervention strategies designed specifically against fusion gene products and causal DNA repair/synthesis pathways. Twit Text FOAVip Chromosomal rearrangements in cancer: Detection and potential causal mechanisms ????Mol Cell Oncol http://www.kidney.de/pget.php?&tw=1&pmid=26203462 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26203462 #FOAvip English Wikipedia <ref>{{Cite pmid|26203462}}</ref> Chromosomal rearrangements in cancer: Detection and potential causal mechanisms #MMPMID26203462 Hasty P; Montagna C Mol Cell Oncol 2014[]; 1 (1): ä PMID26203462show ga Many cancers exhibit chromosomal rearrangements. These rearrangements can be simple, involving a single balanced fusion that preserves the proper complement of genetic information, or complex with one or more fusions that disrupt this balance. Recent technological advances have improved our ability to detect and understand these rearrangements, leading to speculation about potential causal mechanisms such as defective DNA double strand break repair and faulty DNA replication. A better understanding of these potential cancer-causing mechanisms will lead to novel therapeutic regimens to fight cancer. This review describes technological advances in methods used to detect simple and complex chromosomal rearrangements, cancers that exhibit these rearrangements, potential mechanisms for rearrangement of chromosomes, and intervention strategies designed specifically against fusion gene products and causal DNA repair/synthesis pathways. äChromosomal rearrangements in cancer: Detection and potential causal m(epmc).pdf DeepDyve Pubget Overpricing