Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1073/pnas.1506282112 http://scihub22266oqcxt.onion/10.1073/pnas.1506282112 C4507187!4507187!26124092     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26124092.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (28): 8608-13 Nephropedia Template TP {{tp|p=26124092|t=2015. FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP |pdf=|usr=}}{{26124092}} gab.com Text FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26124092 #FOAvip The protein fused-in-sarcoma (FUS) is mutated to cause the neurodegenerative disease amyotrophic lateral sclerosis, but its normal cellular role remains to be understood. Previous work showed that FUS associates with both RNA polymerase II (RNAP II) and the essential splicing factor U1 small nuclear ribonucleoprotein (snRNP). Here we were able to directly investigate the functional significance of these interactions using an in vitro system. We show that FUS is essential for the interaction between U1 snRNP and RNAP II and that FUS must be present during the RNAP II transcription reaction in order for splicing to occur. Together, these data indicate that FUS mediates an interaction between RNAP II and U1 snRNP, thereby physically and functionally coupling transcription to splicing. Twit Text FOAVip FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26124092 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26124092 #FOAvip English Wikipedia <ref>{{Cite pmid|26124092}}</ref> FUS functions in coupling transcription to splicing by mediating an interaction between RNAP II and U1 snRNP #MMPMID26124092 Yu Y; Reed R Proc Natl Acad Sci U S A 2015[Jul]; 112 (28): 8608-13 PMID26124092show ga The protein fused-in-sarcoma (FUS) is mutated to cause the neurodegenerative disease amyotrophic lateral sclerosis, but its normal cellular role remains to be understood. Previous work showed that FUS associates with both RNA polymerase II (RNAP II) and the essential splicing factor U1 small nuclear ribonucleoprotein (snRNP). Here we were able to directly investigate the functional significance of these interactions using an in vitro system. We show that FUS is essential for the interaction between U1 snRNP and RNAP II and that FUS must be present during the RNAP II transcription reaction in order for splicing to occur. Together, these data indicate that FUS mediates an interaction between RNAP II and U1 snRNP, thereby physically and functionally coupling transcription to splicing. äFUS functions in coupling transcription to splicing by mediating an in(epmc).pdf DeepDyve Pubget Overpricing