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10.1038/srep11990 http://scihub22266oqcxt.onion/10.1038/srep11990 C4507173!4507173!26189707     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Rep 2015 ; 5 (ä): ä Nephropedia Template TP {{tp|p=26189707|t=2015. LRP-1-mediated intracellular antibody delivery to the Central Nervous System |pdf=|usr=}}{{26189707}} gab.com Text LRP-1-mediated intracellular antibody delivery to the Central Nervous System JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26189707 #FOAvip The blood-brain barrier (BBB) is by far the most important target in developing new approaches to improve delivery of drugs and diagnostic tools into the Central Nervous System (CNS). Here we report the engineering of pH- sensitive polymersomes (synthetic vesicles formed by amphiphilic copolymers) that exploit endogenous transport mechanisms to traverse the BBB, enabling delivery of large macromolecules into both the CNS parenchyma and CNS cells. We achieve this by targeting the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1) receptor. We show that LRP-1 is associated with endothelial transcytosis that does not involve acidification of cargo in membrane-trafficking organelles. By contrast, this receptor is also associated with traditional endocytosis in CNS cells, thus aiding the delivery of relevant cargo within their cytosol. We prove this using IgG as a model cargo, thus demonstrating that the combination of appropriate targeting combined with pH-sensitive polymersomes enables the efficient delivery of macromolecules into CNS cells. Twit Text FOAVip LRP-1-mediated intracellular antibody delivery to the Central Nervous System ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26189707 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26189707 #FOAvip English Wikipedia <ref>{{Cite pmid|26189707}}</ref> LRP-1-mediated intracellular antibody delivery to the Central Nervous System #MMPMID26189707 Tian X; Nyberg S; S. Sharp P; Madsen J; Daneshpour N; Armes SP; Berwick J; Azzouz M; Shaw P; Abbott NJ; Battaglia G Sci Rep 2015[]; 5 (ä): ä PMID26189707show ga The blood-brain barrier (BBB) is by far the most important target in developing new approaches to improve delivery of drugs and diagnostic tools into the Central Nervous System (CNS). Here we report the engineering of pH- sensitive polymersomes (synthetic vesicles formed by amphiphilic copolymers) that exploit endogenous transport mechanisms to traverse the BBB, enabling delivery of large macromolecules into both the CNS parenchyma and CNS cells. We achieve this by targeting the Low Density Lipoprotein Receptor-Related Protein 1 (LRP-1) receptor. We show that LRP-1 is associated with endothelial transcytosis that does not involve acidification of cargo in membrane-trafficking organelles. By contrast, this receptor is also associated with traditional endocytosis in CNS cells, thus aiding the delivery of relevant cargo within their cytosol. We prove this using IgG as a model cargo, thus demonstrating that the combination of appropriate targeting combined with pH-sensitive polymersomes enables the efficient delivery of macromolecules into CNS cells. äLRP-1-mediated intracellular antibody delivery to the Central Nervous (epmc).pdf DeepDyve Pubget Overpricing