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Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Interferon+Cytokine+Res 2015 ; 35 (7): 554-62 Nephropedia Template TP
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Interferon Lambda Upregulates IDO1 Expression in Respiratory Epithelial Cells After Influenza Virus Infection #MMPMID25756191
Fox JM; Crabtree JM; Sage LK; Tompkins SM; Tripp RA
J Interferon Cytokine Res 2015[Jul]; 35 (7): 554-62 PMID25756191show ga
Influenza infection causes an increase in indoleamine 2, 3-dioxygenase (IDO) activity in the lung parenchyma. IDO catabolizes tryptophan into kynurenine, leading to immune dampening. Multiple cell types express IDO, and while IFN-? upregulates IDO in dendritic cells and macrophages, it is unclear how IDO is affected in respiratory epithelial cells during influenza infection. In this study, the role of IFN-? in IDO regulation was investigated after influenza infection of respiratory epithelial cells. IDO1 expression increased concurrently with IFN-? expression. In differentiated NHBE cells, the IDO metabolite was released basolaterally. Recombinant IFN-? upregulated IDO1 activity, and silencing of IFN-? decreased IDO1 expression during influenza infection. During IFN-? stimulation, most differentiated cell types are able to express IDO but during influenza infection, IDO is primarily expressed in uninfected cells. These studies show a role for IDO in the host response to influenza infection, and they provide insights into novel approaches for enhancing vaccine responses and therapeutic approaches.