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10.1038/ncomms8545 http://scihub22266oqcxt.onion/10.1038/ncomms8545 C4507005!4507005!26151758     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2015 ; 6 (ä): ä Nephropedia Template TP {{tp|p=26151758|t=2015. Genomic modulators of gene expression in human neutrophils |pdf=|usr=}}{{26151758}} gab.com Text Genomic modulators of gene expression in human neutrophils JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26151758 #FOAvip Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil function, with 450 of these not previously observed in myeloid or lymphoid cells. Paired comparison with monocyte eQTL demonstrates nuanced conditioning of genetic regulation of gene expression by cellular context, which relates to cell-type-specific DNA methylation and histone modifications. Neutrophil eQTL are markedly enriched for trait-associated variants particularly autoimmune, allergy and infectious disease. We further demonstrate how eQTL in PADI4 and NOD2 delineate risk variant function in rheumatoid arthritis, leprosy and Crohn?s disease. Taken together, these data help advance understanding of the genetics of gene expression, neutrophil biology and immune-related diseases. Twit Text FOAVip Genomic modulators of gene expression in human neutrophils ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26151758 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26151758 #FOAvip English Wikipedia <ref>{{Cite pmid|26151758}}</ref> Genomic modulators of gene expression in human neutrophils #MMPMID26151758 Naranbhai V; Fairfax BP; Makino S; Humburg P; Wong D; Ng E; Hill AVS; Knight JC Nat Commun 2015[]; 6 (ä): ä PMID26151758show ga Neutrophils form the most abundant leukocyte subset and are central to many disease processes. Technical challenges in transcriptomic profiling have prohibited genomic approaches to date. Here we map expression quantitative trait loci (eQTL) in peripheral blood CD16+ neutrophils from 101 healthy European adults. We identify cis-eQTL for 3281 neutrophil-expressed genes including many implicated in neutrophil function, with 450 of these not previously observed in myeloid or lymphoid cells. Paired comparison with monocyte eQTL demonstrates nuanced conditioning of genetic regulation of gene expression by cellular context, which relates to cell-type-specific DNA methylation and histone modifications. Neutrophil eQTL are markedly enriched for trait-associated variants particularly autoimmune, allergy and infectious disease. We further demonstrate how eQTL in PADI4 and NOD2 delineate risk variant function in rheumatoid arthritis, leprosy and Crohn?s disease. Taken together, these data help advance understanding of the genetics of gene expression, neutrophil biology and immune-related diseases. äGenomic modulators of gene expression in human neutrophils (epmc).pdf DeepDyve Pubget Overpricing