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10.1186/s40659-015-0028-5 http://scihub22266oqcxt.onion/10.1186/s40659-015-0028-5 C4506595!4506595!26187044     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Res 2015 ; 48 (1): ä Nephropedia Template TP {{tp|p=26187044|t=2015. CoagVDb: a comprehensive database for coagulation factors and their associated SAPs |pdf=|usr=}}{{26187044}} gab.com Text CoagVDb: a comprehensive database for coagulation factors and their associated SAPs JO: Biol Res http://www.kidney.de/pget.php?&tw=1&pmid=26187044 #FOAvip The current state of the art in medical genetics is to identify and classify the functional (deleterious) or non-functional (neutral) single amino acid substitutions (SAPs), also known as non-synonymous SNPs (nsSNPs). The primary goal is to elucidate the mechanisms through which functional SAPs exert their effects, and ultimately interrogating this information for association with complex phenotypes. This work focuses on coagulation factors involved in the coagulation cascade pathway which plays a vital role in the maintenance of homeostasis in the human system. We developed an integrated coagulation variation database, CoagVDb, which makes use of the biological information from various public databases such as NCBI, OMIM, UniProt, PDB and SAPs (rsIDs/variant). CoagVDb enriched with computational prediction scores classify SAPs as either deleterious or tolerated. Also, various other properties are incorporated such as amino acid composition, secondary structure elements, solvent accessibility, ordered/disordered regions, conservation, and the presence of disulfide bonds. This specialized database provides integration of various prediction scores from different computational methods along with gene, protein, and disease information. We hope our database will act as a useful reference resource for hematologists to reveal protein structure?function relationship and disease genotype?phenotype correlation.Electronic supplementary material: The online version of this article (doi:10.1186/s40659-015-0028-5) contains supplementary material, which is available to authorized users. Twit Text FOAVip CoagVDb: a comprehensive database for coagulation factors and their associated SAPs ????Biol Res http://www.kidney.de/pget.php?&tw=1&pmid=26187044 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26187044 #FOAvip English Wikipedia <ref>{{Cite pmid|26187044}}</ref> CoagVDb: a comprehensive database for coagulation factors and their associated SAPs #MMPMID26187044 Ali SK; Doss CGP; Kumar DT; Zhu H Biol Res 2015[]; 48 (1): ä PMID26187044show ga The current state of the art in medical genetics is to identify and classify the functional (deleterious) or non-functional (neutral) single amino acid substitutions (SAPs), also known as non-synonymous SNPs (nsSNPs). The primary goal is to elucidate the mechanisms through which functional SAPs exert their effects, and ultimately interrogating this information for association with complex phenotypes. This work focuses on coagulation factors involved in the coagulation cascade pathway which plays a vital role in the maintenance of homeostasis in the human system. We developed an integrated coagulation variation database, CoagVDb, which makes use of the biological information from various public databases such as NCBI, OMIM, UniProt, PDB and SAPs (rsIDs/variant). CoagVDb enriched with computational prediction scores classify SAPs as either deleterious or tolerated. Also, various other properties are incorporated such as amino acid composition, secondary structure elements, solvent accessibility, ordered/disordered regions, conservation, and the presence of disulfide bonds. This specialized database provides integration of various prediction scores from different computational methods along with gene, protein, and disease information. We hope our database will act as a useful reference resource for hematologists to reveal protein structure?function relationship and disease genotype?phenotype correlation.Electronic supplementary material: The online version of this article (doi:10.1186/s40659-015-0028-5) contains supplementary material, which is available to authorized users. äCoagVDb: a comprehensive database for coagulation factors and their as(epmc).pdf DeepDyve Pubget Overpricing