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10.1371/journal.pone.0133278 http://scihub22266oqcxt.onion/10.1371/journal.pone.0133278 C4506049!4506049 !26186634     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26186634 &cmd=llinks): Failed to open stream: HTTP request failed! 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Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy |pdf=|usr=}}{{26186634 }} gab.com Text Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26186634 #FOAvip BACKGROUND: Phosphate burden in chronic kidney disease (CKD) leads to elevated serum fibroblast factor-23 (FGF-23) levels, secondary hyperparathyroidism and chronic kidney disease-mineral bone disorder (CKD-MBD). However dissociated hyperphosphatemia and low serum FGF-23 concentrations have been observed in experimentally parathyoridectomized rats. The relationships between serum mineral, hormone, and bone metabolism may be altered in the presence of CKD. The aim of our study was to investigate whether a consistent relationship existed between serum FGF-23 levels, specific serum biochemical markers, and histomorphometric parameters of bone metabolism in a parathyroidectomized CKD animal model. RESULTS: Sprague Dawley rats were divided into 3 groups: parathyroidectomy (PTX) and CKD (PTX+CKD, 9 rats), CKD without PTX (CKD, 9 rats), and neither PTX nor CKD (sham-operated control, 8 rats); CKD was induced by partial nephrectomy. At 8 weeks after partial nephrectomy, serum biomarkers were measured. Bone histomorphometries of the distal femoral metaphyseal bone were analyzed. The mean serum FGF-23 levels and mean bone formation rate were the highest in the CKD group and the lowest in the PTX+CKD group. Bone volume parameters increased significantly in the PTX+CKD group. Pearson's correlation revealed that serum FGF-23 levels associated with those of intact parathyroid hormone, phosphate, collagen type I C-telopeptide, and calcium. Univariate linear regression showed that serum FGF-23 values correlated with bone formation rate, bone volume, and osteoid parameters. Stepwise multivariate regression analysis revealed that circulating FGF-23 values were independently associated with bone volume and thickness (? = -0.737; p < 0.001 and ? = -0.526; p = 0.006, respectively). Serum parathyroid hormone levels independently correlated with bone formation rate (? = 0.714; p < 0.001) while collagen type I C-telopeptide levels correlated with osteoid parameter. CONCLUSION: Serum FGF-23 levels independently correlated with bone volume parameters in rats with experimentally induced CKD. Twit Text FOAVip Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=26186634 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26186634 #FOAvip English Wikipedia <ref>{{Cite pmid|26186634 }}</ref> Relationship between Fibroblast Growth Factor 23 and Biochemical and Bone Histomorphometric Alterations in a Chronic Kidney Disease Rat Model Undergoing Parathyroidectomy #MMPMID26186634 Liao HW ; Hung PH ; Hsiao CY ; Liou HH ; Lin HS ; Huang TH ; Jou IM ; Tsai KJ PLoS One 2015[]; 10 (7 ): e0133278 PMID26186634 show ga BACKGROUND: Phosphate burden in chronic kidney disease (CKD) leads to elevated serum fibroblast factor-23 (FGF-23) levels, secondary hyperparathyroidism and chronic kidney disease-mineral bone disorder (CKD-MBD). However dissociated hyperphosphatemia and low serum FGF-23 concentrations have been observed in experimentally parathyoridectomized rats. The relationships between serum mineral, hormone, and bone metabolism may be altered in the presence of CKD. The aim of our study was to investigate whether a consistent relationship existed between serum FGF-23 levels, specific serum biochemical markers, and histomorphometric parameters of bone metabolism in a parathyroidectomized CKD animal model. RESULTS: Sprague Dawley rats were divided into 3 groups: parathyroidectomy (PTX) and CKD (PTX+CKD, 9 rats), CKD without PTX (CKD, 9 rats), and neither PTX nor CKD (sham-operated control, 8 rats); CKD was induced by partial nephrectomy. At 8 weeks after partial nephrectomy, serum biomarkers were measured. Bone histomorphometries of the distal femoral metaphyseal bone were analyzed. The mean serum FGF-23 levels and mean bone formation rate were the highest in the CKD group and the lowest in the PTX+CKD group. Bone volume parameters increased significantly in the PTX+CKD group. Pearson's correlation revealed that serum FGF-23 levels associated with those of intact parathyroid hormone, phosphate, collagen type I C-telopeptide, and calcium. Univariate linear regression showed that serum FGF-23 values correlated with bone formation rate, bone volume, and osteoid parameters. Stepwise multivariate regression analysis revealed that circulating FGF-23 values were independently associated with bone volume and thickness (? = -0.737; p < 0.001 and ? = -0.526; p = 0.006, respectively). Serum parathyroid hormone levels independently correlated with bone formation rate (? = 0.714; p < 0.001) while collagen type I C-telopeptide levels correlated with osteoid parameter. CONCLUSION: Serum FGF-23 levels independently correlated with bone volume parameters in rats with experimentally induced CKD. |Animals [MESH] |Biomarkers/blood [MESH] |Bone and Bones/*chemistry/pathology [MESH] |Calcium/blood [MESH] |Collagen Type I/blood [MESH] |Fibroblast Growth Factor-23 [MESH] |Fibroblast Growth Factors/*blood [MESH] |Hyperphosphatemia/*blood [MESH] |Male [MESH] |Multivariate Analysis [MESH] |Parathyroid Hormone/blood [MESH] |Parathyroidectomy/*methods [MESH] |Peptides/blood [MESH] |Phosphates/blood [MESH] |Rats, Sprague-Dawley [MESH] |Regression Analysis [MESH]Relationship between Fibroblast Growth Factor 23 and Biochemical and B(epmc).pdf DeepDyve Pubget Overpricing