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10.2147/OTT.S86743 http://scihub22266oqcxt.onion/10.2147/OTT.S86743 C4506035!4506035!26203260     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Onco+Targets+Ther 2015 ; 8 (ä): 1701-6 Nephropedia Template TP {{tp|p=26203260|t=2015. Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury |pdf=|usr=}}{{26203260}} gab.com Text Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury JO: Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=26203260 #FOAvip Background/aim: To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. Materials and methods: To detect changing expression of MATE1/SLC47A1 in dose- and time-dependent manners, human proximal tubular epithelial cells were incubated with AGE-aggregated-human serum albumin. As a function assay for MATE1/SLC47A1, human proximal tubular epithelial cells were incubated with cisplatin or carboplatin. Results: On incubation with AGEs, the expressions of MATE1/SLC47A1 were decreased in tubular cells. In addition, the toxicities of cisplatin were increased in tubular cells that had been pretreated with AGEs. However, the toxicities of carboplatin were smaller than that of cisplatin in proximal tubular epithelial cells. Conclusion: The expression of the MATE1/SLC47A1 is decreased by AGEs, which increases the risk for proximal tubular injury. Twit Text FOAVip Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury ????Onco Targets Ther http://www.kidney.de/pget.php?&tw=1&pmid=26203260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26203260 #FOAvip English Wikipedia <ref>{{Cite pmid|26203260}}</ref> Significance of downregulation of renal organic cation transporter (SLC47A1) in cisplatin-induced proximal tubular injury #MMPMID26203260 Mizuno T; Sato W; Ishikawa K; Terao Y; Takahashi K; Noda Y; Yuzawa Y; Nagamatsu T Onco Targets Ther 2015[]; 8 (ä): 1701-6 PMID26203260show ga Background/aim: To elucidate the mechanism responsible for developing acute kidney injury in patients with diabetes mellitus, we also evaluated the issue of whether advanced glycation endproducts (AGEs) influence the expressions of multi antimicrobial extrusion protein (MATE1/SLC47A1) in tubular cells. Materials and methods: To detect changing expression of MATE1/SLC47A1 in dose- and time-dependent manners, human proximal tubular epithelial cells were incubated with AGE-aggregated-human serum albumin. As a function assay for MATE1/SLC47A1, human proximal tubular epithelial cells were incubated with cisplatin or carboplatin. Results: On incubation with AGEs, the expressions of MATE1/SLC47A1 were decreased in tubular cells. In addition, the toxicities of cisplatin were increased in tubular cells that had been pretreated with AGEs. However, the toxicities of carboplatin were smaller than that of cisplatin in proximal tubular epithelial cells. Conclusion: The expression of the MATE1/SLC47A1 is decreased by AGEs, which increases the risk for proximal tubular injury. äSignificance of downregulation of renal organic cation transporter (SL(epmc).pdf DeepDyve Pubget Overpricing