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2015 ; 2
(2
): ofv021
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Influenza Circulation in United States Army Training Camps Before and During the
1918 Influenza Pandemic: Clues to Early Detection of Pandemic Viral Emergence
#MMPMID26361632
Chertow DS
; Cai R
; Sun J
; Grantham J
; Taubenberger JK
; Morens DM
Open Forum Infect Dis
2015[Apr]; 2
(2
): ofv021
PMID26361632
show ga
Background. ?Surveillance for respiratory diseases in domestic National Army and
National Guard training camps began after the United States' entry into World War
I, 17 months before the "Spanish influenza" pandemic appeared. Methods.
?Morbidity, mortality, and case-fatality data from 605 625 admissions and 18 258
deaths recorded for 7 diagnostic categories of respiratory diseases, including
influenza and pneumonia, were examined over prepandemic and pandemic periods.
Results. ?High pandemic influenza mortality was primarily due to increased
incidence of, but not increased severity of, secondary bacterial pneumonias.
Conclusions. ?Two prepandemic incidence peaks of probable influenza, in December
1917-January 1918 and in March-April 1918, differed markedly from the
September-October 1918 pandemic onset peak in their clinical-epidemiologic
features, and they may have been caused by seasonal or endemic viruses.
Nevertheless, rising proportions of very low incidence postinfluenza
bronchopneumonia (diagnosed at the time as influenza and bronchopneumonia) in
early 1918 could have reflected circulation of the pandemic virus 5 months before
it emerged in pandemic form. In this study, we discuss the possibility of
detecting pandemic viruses before they emerge, by surveillance of special
populations.