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10.4049/jimmunol.1403038 http://scihub22266oqcxt.onion/10.4049/jimmunol.1403038 C4505953!4505953!26116513     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 195 (3): 934-43 Nephropedia Template TP {{tp|p=26116513|t=2015. mTOR Complex Signaling through the SEMA4A?Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells |pdf=|usr=}}{{26116513}} gab.com Text mTOR Complex Signaling through the SEMA4A Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26116513 #FOAvip Mammalian target of rapamycin (mTOR) plays crucial roles in activation and differentiation of diverse types of immune cells. Although several lines of evidence have demonstrated the importance of mTOR-mediated signals in CD4+ T cell responses, the involvement of mTOR in CD8+ T cell responses is not fully understood. In this study, we show that a class IV semaphorin, SEMA4A, regulates CD8+ T cell activation and differentiation through activation of mTOR complex (mTORC) 1. SEMA4A?/? CD8+ T cells exhibited impairments in production of IFN-? and TNF-? and induction of the effector molecules granzyme B, perforin, and FAS-L. Upon infection with OVA-expressing Listeria monocytogenes, pathogen-specific effector CD8+ T cell responses were significantly impaired in SEMA4A?/? mice. Furthermore, SEMA4A?/? CD8+ T cells exhibited reduced mTORC1 activity and elevated mTORC2 activity, suggesting that SEMA4A is required for optimal activation of mTORC1 in CD8+ T cells. IFN-? production and mTORC1 activity in SEMA4A?/? CD8+ T cells were restored by administration of recombinant Sema4A protein. In addition, we show that plexin B2 is a functional receptor of SEMA4A in CD8+ T cells. Collectively, these results not only demonstrate the role of SEMA4A in CD8+ T cells, but also reveal a novel link between a semaphorin and mTOR signaling. Twit Text FOAVip mTOR Complex Signaling through the SEMA4A Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26116513 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26116513 #FOAvip English Wikipedia <ref>{{Cite pmid|26116513}}</ref> mTOR Complex Signaling through the SEMA4A?Plexin B2 Axis Is Required for Optimal Activation and Differentiation of CD8+ T Cells #MMPMID26116513 Ito D; Nojima S; Nishide M; Okuno T; Takamatsu H; Kang S; Kimura T; Yoshida Y; Morimoto K; Maeda Y; Hosokawa T; Toyofuku T; Ohshima J; Kamimura D; Yamamoto M; Murakami M; Morii E; Rakugi H; Isaka Y; Kumanogoh A J Immunol 2015[Aug]; 195 (3): 934-43 PMID26116513show ga Mammalian target of rapamycin (mTOR) plays crucial roles in activation and differentiation of diverse types of immune cells. Although several lines of evidence have demonstrated the importance of mTOR-mediated signals in CD4+ T cell responses, the involvement of mTOR in CD8+ T cell responses is not fully understood. In this study, we show that a class IV semaphorin, SEMA4A, regulates CD8+ T cell activation and differentiation through activation of mTOR complex (mTORC) 1. SEMA4A?/? CD8+ T cells exhibited impairments in production of IFN-? and TNF-? and induction of the effector molecules granzyme B, perforin, and FAS-L. Upon infection with OVA-expressing Listeria monocytogenes, pathogen-specific effector CD8+ T cell responses were significantly impaired in SEMA4A?/? mice. Furthermore, SEMA4A?/? CD8+ T cells exhibited reduced mTORC1 activity and elevated mTORC2 activity, suggesting that SEMA4A is required for optimal activation of mTORC1 in CD8+ T cells. IFN-? production and mTORC1 activity in SEMA4A?/? CD8+ T cells were restored by administration of recombinant Sema4A protein. In addition, we show that plexin B2 is a functional receptor of SEMA4A in CD8+ T cells. Collectively, these results not only demonstrate the role of SEMA4A in CD8+ T cells, but also reveal a novel link between a semaphorin and mTOR signaling. ämTOR Complex Signaling through the SEMA4A?Plexin B2 Axis Is Required f(epmc).pdf DeepDyve Pubget Overpricing