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2015 ; 10
(7
): e0133199
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English Wikipedia
Use of Multifrequency Bioimpedance Analysis in Male Patients with Acute Kidney
Injury Who Are Undergoing Continuous Veno-Venous Hemodiafiltration
#MMPMID26186370
Rhee H
; Jang KS
; Shin MJ
; Lee JW
; Kim IY
; Song SH
; Lee DW
; Lee SB
; Kwak IS
; Seong EY
PLoS One
2015[]; 10
(7
): e0133199
PMID26186370
show ga
INTRODUCTION: Fluid overload is a well-known predictor of mortality in patients
with acute kidney injury (AKI). Multifrequency bioimpedance analysis (MF-BIA) is
a promising tool for quantifying volume status. However, few studies have
analyzed the effect of MF-BIA-defined volume status on the mortality of
critically ill patients with AKI. This retrospective medical research study aimed
to investigate this issue. METHODS: We retrospectively reviewed the medical
records of patients with AKI who underwent continuous veno-venous
hemodiafiltration (CVVHDF) from Jan. 2013 to Feb. 2014. Female patients were
excluded to control for sex-based differences. Volume status was measured using
MF-BIA (Inbody S20, Seoul, Korea) at the time of CVVHDF initiation, and volume
parameters were adjusted with height squared (H2). Binary logistic regression
analyses were performed to test independent factors for prediction of in-hospital
mortality. RESULTS: A total of 208 male patients were included in this study. The
mean age was 65.19±12.90 years. During the mean ICU stay of 18.29±27.48 days,
40.4% of the patients died. The in-hospital mortality rate increased with
increasing total body water (TBW)/H2 quartile. In the multivariable analyses,
increased TBW/H2 (OR 1.312(1.009-1.705), p=0.043) and having lower serum albumin
(OR 0.564(0.346-0.919, p=0.022) were independently associated with higher
in-hospital mortality. When the intracellular water (ICW)/H2 or extracellular
water (ECW)/H2 was adjusted instead of the TBW/H2, only excess ICW/H2 was
independently associated with increased mortality (OR 1.561(1.012-2.408,
p=0.044). CONCLUSIONS: MF-BIA-defined excess TBW/H2 and ICW/H2 are independently
associated with higher in-hospital mortality in male patients with AKI undergoing
CVVHDF.