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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Comput+Assist+Radiol+Surg 2015 ; 10 (4): 393-401 Nephropedia Template TP
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Morphometry-based measurements of the structural response to whole-brain radiation #MMPMID25408306
Fuentes D; Contreras J; Yu J; He R; Castillo E; Castillo R; Guerrero T
Int J Comput Assist Radiol Surg 2015[Apr]; 10 (4): 393-401 PMID25408306show ga
Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies. Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures. Results: An average cerebral volume atrophy of ?0.2 and ?3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively. Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.