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10.1007/s11548-014-1128-3

http://scihub22266oqcxt.onion/10.1007/s11548-014-1128-3
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C4505795!4505795!25408306
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suck abstract from ncbi


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pmid25408306      Int+J+Comput+Assist+Radiol+Surg 2015 ; 10 (4): 393-401
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  • Morphometry-based measurements of the structural response to whole-brain radiation #MMPMID25408306
  • Fuentes D; Contreras J; Yu J; He R; Castillo E; Castillo R; Guerrero T
  • Int J Comput Assist Radiol Surg 2015[Apr]; 10 (4): 393-401 PMID25408306show ga
  • Purpose: Morphometry techniques were applied to quantify the normal tissue therapy response in patients receiving whole-brain radiation for intracranial malignancies. Methods: Pre- and Post-irradiation magnetic resonance imaging (MRI) data sets were retrospectively analyzed in N = 15 patients. Volume changes with respect to pre-irradiation were quantitatively measured in the cerebrum and ventricles. Measurements were correlated with the time interval from irradiation. Criteria for inclusion included craniospinal irradiation, pre-irradiation MRI, at least one follow-up MRI, and no disease progression. The brain on each image was segmented to remove the skull and registered to the initial pre-treatment scan. Average volume changes were measured using morphometry analysis of the deformation Jacobian and direct template registration-based segmentation of brain structures. Results: An average cerebral volume atrophy of ?0.2 and ?3 % was measured for the deformation morphometry and direct segmentation methods, respectively. An average ventricle volume dilation of 21 and 20 % was measured for the deformation morphometry and direct segmentation methods, respectively. Conclusion: The presented study has developed an image processing pipeline for morphometric monitoring of brain tissue volume changes as a response to radiation therapy. Results indicate that quantitative morphometric monitoring is feasible and may provide additional information in assessing response.
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