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10.1016/j.cell.2008.01.038

http://scihub22266oqcxt.onion/10.1016/j.cell.2008.01.038
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C4505728!4505728!18295578
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suck abstract from ncbi


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pmid18295578      Cell 2008 ; 132 (4): 598-611
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  • Stem cells and niches: mechanisms that promote stem cell maintenance throughout life #MMPMID18295578
  • Morrison SJ; Spradling AC
  • Cell 2008[Feb]; 132 (4): 598-611 PMID18295578show ga
  • Niches are local tissue microenvironments that maintain and regulate stem cells. Long-predicted from mammalian studies, these structures have recently been characterized within several invertebrate tissues using methods that reliably identify individual stem cells and their functional requirements. Although, similar single-cell resolution has not usually been achieved in mammalian tissues, principles likely to govern the behavior of niches in diverse organisms are beginning to emerge and considerable progress has been made elucidating the microenvironmental mechanisms that promote stem cell maintenance. These mechanisms may not only guide tissue homeostasis but when altered during adulthood likely contribute to aging and tumorigenesis.
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