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10.1364/BOE.6.002624

http://scihub22266oqcxt.onion/10.1364/BOE.6.002624
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C4505714!4505714!26203386
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suck abstract from ncbi


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pmid26203386      Biomed+Opt+Express 2015 ; 6 (7): 2624-32
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  • Directional migration of cancer cells induced by a blue light intensity gradient #MMPMID26203386
  • Lan CC; Lu EY; Pan HJ; Lee CH
  • Biomed Opt Express 2015[Jul]; 6 (7): 2624-32 PMID26203386show ga
  • We used a spatial light modulator to project an optical micropattern of 473 nm light with a quartic intensity gradient on a single lung cancer cell. We observed that the intracellular amounts of reactive oxygen species (ROS) of the cancer cells were proportional to the intensity of the blue light, and the blue light intensity gradients could drive directional cell migration. This optically induced directional cell migration was inhibited by a ROS scavenger in the culture medium in a dose-dependent manner. In contrast, the ROS levels in fibroblasts were saturated by the blue light at low intensity and therefore the fibroblasts did not exhibit directional migration in the intensity gradient.
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