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10.1074/jbc.R115.650416 http://scihub22266oqcxt.onion/10.1074/jbc.R115.650416 C4505552!4505552!25855792     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2015 ; 290 (21): 12975-83 Nephropedia Template TP {{tp|p=25855792|t=2015. Signaling, Regulation, and Specificity of the Type II p21-activated Kinases* |pdf=|usr=}}{{25855792}} gab.com Text Signaling, Regulation, and Specificity of the Type II p21-activated Kinases* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25855792 #FOAvip The p21-activated kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RHO family GTPases in mammalian cells. PAKs are subdivided into two groups: type I PAKs (PAK1, PAK2, and PAK3) and type II PAKs (PAK4, PAK5, and PAK6). Although these groups are involved in common signaling pathways, recent work indicates that the two groups have distinct modes of regulation and have both unique and common substrates. Here, we review recent insights into the molecular level details that govern regulation of type II PAK signaling. We also consider mechanisms by which signal transduction is regulated at the level of substrate specificity. Finally, we discuss the implications of these studies for clinical targeting of these kinases. Twit Text FOAVip Signaling, Regulation, and Specificity of the Type II p21-activated Kinases* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25855792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25855792 #FOAvip English Wikipedia <ref>{{Cite pmid|25855792}}</ref> Signaling, Regulation, and Specificity of the Type II p21-activated Kinases* #MMPMID25855792 Ha BH; Morse EM; Turk BE; Boggon TJ J Biol Chem 2015[May]; 290 (21): 12975-83 PMID25855792show ga The p21-activated kinases (PAKs) are a family of six serine/threonine kinases that act as key effectors of RHO family GTPases in mammalian cells. PAKs are subdivided into two groups: type I PAKs (PAK1, PAK2, and PAK3) and type II PAKs (PAK4, PAK5, and PAK6). Although these groups are involved in common signaling pathways, recent work indicates that the two groups have distinct modes of regulation and have both unique and common substrates. Here, we review recent insights into the molecular level details that govern regulation of type II PAK signaling. We also consider mechanisms by which signal transduction is regulated at the level of substrate specificity. Finally, we discuss the implications of these studies for clinical targeting of these kinases. äSignaling, Regulation, and Specificity of the Type II p21-activated Ki(epmc).pdf DeepDyve Pubget Overpricing