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10.1074/jbc.M114.630368

http://scihub22266oqcxt.onion/10.1074/jbc.M114.630368
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C4505537!4505537!25918170
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suck abstract from ncbi


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pmid25918170      J+Biol+Chem 2015 ; 290 (23): 14717-28
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  • Transforming Growth Factor-? and Interleukin-1? Signaling Pathways Converge on the Chemokine CCL20 Promoter* #MMPMID25918170
  • Brand OJ; Somanath S; Moermans C; Yanagisawa H; Hashimoto M; Cambier S; Markovics J; Bondesson AJ; Hill A; Jablons D; Wolters P; Lou J; Marks JD; Baron JL; Nishimura SL
  • J Biol Chem 2015[Jun]; 290 (23): 14717-28 PMID25918170show ga
  • Background: Mechanisms that drive chronic inflammation in airway disease are not well understood.Results: We demonstrate a TGF-?-responsive enhancer element required for efficient IL-1?-dependent expression of the proinflammatory chemokine CCL20 by human lung fibroblasts.Conclusion: Convergence of TGF-? and IL-1? signaling pathways on the CCL20 promoter are required for efficient fibroblast expression of CCL20.Significance: These findings identify potential targets to reduce chronic inflammation in airway disease.
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