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10.1074/jbc.M115.653600

http://scihub22266oqcxt.onion/10.1074/jbc.M115.653600
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C4505508!4505508!25847237
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suck abstract from ncbi


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pmid25847237      J+Biol+Chem 2015 ; 290 (23): 14407-17
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  • Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis* #MMPMID25847237
  • Rahman MA; Sobia P; Dwivedi VP; Bhawsar A; Singh DK; Sharma P; Moodley P; Van Kaer L; Bishai WR; Das G
  • J Biol Chem 2015[Jun]; 290 (23): 14407-17 PMID25847237show ga
  • Background: TlyA is a virulence factor in several bacterial infections and is evolutionarily conserved in many Gram-positive bacteria, but its function in Mycobacterium tuberculosis pathogenesis has not been elucidated.Results: TlyA mutant M. tuberculosis induces enhanced host-protective Th1 and Th17 responses.Conclusion: TlyA significantly contributes to the pathogenesis of M. tuberculosis.Significance: TlyA warrants consideration for designing TB vaccines and therapies.
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