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10.1074/jbc.M115.653394

http://scihub22266oqcxt.onion/10.1074/jbc.M115.653394
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C4505496!4505496!25837255
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suck abstract from ncbi


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pmid25837255      J+Biol+Chem 2015 ; 290 (23): 14267-76
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  • Spatial Control of Epsin-induced Clathrin Assembly by Membrane Curvature*? #MMPMID25837255
  • Holkar SS; Kamerkar SC; Pucadyil TJ
  • J Biol Chem 2015[Jun]; 290 (23): 14267-76 PMID25837255show ga
  • Background: The clathrin adaptor epsin is indispensable for clathrin-mediated endocytosis, but the mechanism by which it regulates clathrin assembly remains unclear.Results: Epsin shows a preference to localize to regions of high membrane curvature.Conclusion: Epsin's membrane curvature sensing directs clathrin assembly to highly curved membranes.Significance: Membrane curvature could determine the hierarchy of molecular interactions during clathrin-mediated membrane budding.
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