Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1074/jbc.M115.643700 http://scihub22266oqcxt.onion/10.1074/jbc.M115.643700 C4505479!4505479 !25922067     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25922067 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2015 ; 290 (25 ): 15687-15696 Nephropedia Template TP {{tp|p=25922067 |t=2015. Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor ?B (NF-?B) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide |pdf=|usr=}}{{25922067 }} gab.com Text Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor B (NF- B) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25922067 #FOAvip The NF-?B transcriptional response is tightly regulated by a number of processes including the phosphorylation, ubiquitination, and subsequent proteasomal degradation of NF-?B subunits. The I?B family protein BCL-3 stabilizes a NF-?B p50 homodimer·DNA complex through inhibition of p50 ubiquitination. This complex inhibits the binding of the transcriptionally active NF-?B subunits p65 and c-Rel on the promoters of NF-?B target genes and functions to suppress inflammatory gene expression. We have previously shown that the direct interaction between p50 and BCL-3 is required for BCL-3-mediated inhibition of pro-inflammatory gene expression. In this study we have used immobilized peptide array technology to define regions of BCl-3 that mediate interaction with p50 homodimers. Our data show that BCL-3 makes extensive contacts with p50 homodimers and in particular with ankyrin repeats (ANK) 1, 6, and 7, and the N-terminal region of Bcl-3. Using these data we have designed a BCL-3 mimetic peptide based on a region of the ANK1 of BCL-3 that interacts with p50 and shares low sequence similarity with other I?B proteins. When fused to a cargo carrying peptide sequence this BCL-3-derived peptide, but not a mutated peptide, inhibited Toll-like receptor-induced cytokine expression in vitro. The BCL-3 mimetic peptide was also effective in preventing inflammation in vivo in the carrageenan-induced paw edema mouse model. This study demonstrates that therapeutic strategies aimed at mimicking the functional activity of BCL-3 may be effective in the treatment of inflammatory disease. Twit Text FOAVip Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor B (NF- B) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=25922067 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25922067 #FOAvip English Wikipedia <ref>{{Cite pmid|25922067 }}</ref> Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Factor ?B (NF-?B) p50 Identifies a BCL-3-mimetic Anti-inflammatory Peptide #MMPMID25922067 Collins PE ; Grassia G ; Colleran A ; Kiely PA ; Ialenti A ; Maffia P ; Carmody RJ J Biol Chem 2015[Jun]; 290 (25 ): 15687-15696 PMID25922067 show ga The NF-?B transcriptional response is tightly regulated by a number of processes including the phosphorylation, ubiquitination, and subsequent proteasomal degradation of NF-?B subunits. The I?B family protein BCL-3 stabilizes a NF-?B p50 homodimer·DNA complex through inhibition of p50 ubiquitination. This complex inhibits the binding of the transcriptionally active NF-?B subunits p65 and c-Rel on the promoters of NF-?B target genes and functions to suppress inflammatory gene expression. We have previously shown that the direct interaction between p50 and BCL-3 is required for BCL-3-mediated inhibition of pro-inflammatory gene expression. In this study we have used immobilized peptide array technology to define regions of BCl-3 that mediate interaction with p50 homodimers. Our data show that BCL-3 makes extensive contacts with p50 homodimers and in particular with ankyrin repeats (ANK) 1, 6, and 7, and the N-terminal region of Bcl-3. Using these data we have designed a BCL-3 mimetic peptide based on a region of the ANK1 of BCL-3 that interacts with p50 and shares low sequence similarity with other I?B proteins. When fused to a cargo carrying peptide sequence this BCL-3-derived peptide, but not a mutated peptide, inhibited Toll-like receptor-induced cytokine expression in vitro. The BCL-3 mimetic peptide was also effective in preventing inflammation in vivo in the carrageenan-induced paw edema mouse model. This study demonstrates that therapeutic strategies aimed at mimicking the functional activity of BCL-3 may be effective in the treatment of inflammatory disease. |*Anti-Inflammatory Agents/chemistry/pharmacology [MESH] |*Biomimetic Materials/chemistry/pharmacology [MESH] |*NF-kappa B p50 Subunit/chemistry/genetics/metabolism [MESH] |*Peptides/chemistry/pharmacology [MESH] |*Proto-Oncogene Proteins/chemistry/genetics/metabolism [MESH] |*Transcription Factors/chemistry/genetics/metabolism [MESH] |Animals [MESH] |Ankyrin Repeat [MESH] |B-Cell Lymphoma 3 Protein [MESH] |Disease Models, Animal [MESH] |Edema/drug therapy/genetics/metabolism/pathology [MESH] |Gene Expression Regulation [MESH] |HeLa Cells [MESH] |Humans [MESH] |Mice [MESH] |Peptide Mapping [MESH] |Protein Binding [MESH]Mapping the Interaction of B Cell Leukemia 3 (BCL-3) and Nuclear Facto(epmc).pdf DeepDyve Pubget Overpricing