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10.1074/jbc.M115.646034

http://scihub22266oqcxt.onion/10.1074/jbc.M115.646034
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C4505433!4505433!26013827
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suck abstract from ncbi


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pmid26013827      J+Biol+Chem 2015 ; 290 (27): 16873-81
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  • Identification and Molecular Mechanisms of the Rapid Tonicity-induced Relocalization of the Aquaporin 4 Channel* #MMPMID26013827
  • Kitchen P; Day RE; Taylor LHJ; Salman MM; Bill RM; Conner MT; Conner AC
  • J Biol Chem 2015[Jul]; 290 (27): 16873-81 PMID26013827show ga
  • Background: The water channel protein aquaporin 4 (AQP4) controls water permeability of the blood-brain barrier.Results: Hypotonicity induces rapid relocalization of AQP4 in a calcium-, calmodulin-, and kinase-dependent manner.Conclusion: AQP4 can be relocalized between the cell membrane and intracellular compartments.Significance: Pharmacological modulation of AQP4 membrane localization could provide a new approach to treating brain edema.
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