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2015 ; 20
(2
): 74-8
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Alternative biomarkers for assessing glycemic control in diabetes: fructosamine,
glycated albumin, and 1,5-anhydroglucitol
#MMPMID26191510
Lee JE
Ann Pediatr Endocrinol Metab
2015[Jun]; 20
(2
): 74-8
PMID26191510
show ga
The growing attention to alternative glycemic biomarkers including fructosamine,
glycated albumin (GA), 1,5-anhydroglucitol (1,5-AG), is attributable to the
limitations of the glycated hemoglobin (HbA1c) assay. It is important to
recognize the conditions in which HbA1c levels may be difficult to interpret.
Serum fructosamine and GA have been proposed useful tools for monitoring of
short-term glycemic control. These biomarkers not only reflect well glycemic
control in hematologic disorder, but also represent postprandial glucose
fluctuation. Serum 1,5-AG may be useful for estimating within-day glucose
variation. Use of these nontraditional tests can be more helpful in the
management of diabetes as complement traditional measures. Further larger cohort
studies are warranted to determine whether nontraditional biomarkers have
potential utility for early diagnosis, management of diabetes, and prevention of
diabetic complications.