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2005 ; 11
(25
): 3855-9
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Expression and significance of new inhibitor of apoptosis protein survivin in
hepatocellular carcinoma
#MMPMID15991282
Zhu H
; Chen XP
; Zhang WG
; Luo SF
; Zhang BX
World J Gastroenterol
2005[Jul]; 11
(25
): 3855-9
PMID15991282
show ga
AIM: To investigate expression and significance of inhibitor of apoptosis protein
survivin in hepatocellular carcinoma (HCC). METHODS: The expression of survivin
and vascular endothelial growth factor (VEGF) was investigated in 38 cases of HCC
tissues and 38 liver cirrhosis tissues by immunohistochemistry and Western blot.
The relationship between the expression of survivin and clinicopathological
factors of HCC was analyzed. RESULTS: Survivin protein was detected in 23 (60.5%)
of 38 HCCs and 3 (7.9%) of 38 liver cirrhosis tissues. In 23 cases of HCC which
expressed survivin, the expression of VEGF was positive in 18 cases and slight
positive or negative in 5 cases. While in 15 cases of HCC which did not express
survivin, 12 cases did not express or slightly expressed, and 3 cases expressed
VEGF. In liver cirrhosis tissues, the expression of VEGF was as follows: 24 cases
were negative, 10 cases were weak positive and 4 cases were strong positive. The
expression of survivin was coincident with the expression of VEGF in HCC
(P<0.01). The expression of survivin in HCC had no relationship with the
patients' age, gender, tumor size and differentiation level of HCC, while it was
related to the metastasis of HCC. The protein quantitative analysis by Western
blot also showed that overexpression of survivin in HCC was closely correlated to
the expression of VEGF (P<0.01). Furthermore, stronger expression of survivin and
VEGF was also found in patients with metastasis rather than in those with no
metastasis (P<0.01). CONCLUSION: Survivin plays a pivotal role in the metastasis
of HCC, and it has some correlation with tumorigenesis. The expression of
survivin in the primary lesion is very useful as an indicator for metastasis and
prognosis of HCC. It could become a new target of gene therapy of HCC.
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