Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Adv+Drug+Deliv+Rev 2015 ; 87 (ä): 25-34 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
DNA and RNA Derivatives to Optimize Distribution and Delivery #MMPMID25912659
Wickstrom E
Adv Drug Deliv Rev 2015[Jun]; 87 (ä): 25-34 PMID25912659show ga
Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).