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10.1016/j.addr.2015.04.012

http://scihub22266oqcxt.onion/10.1016/j.addr.2015.04.012
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C4504810!4504810!25912659
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suck abstract from ncbi


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pmid25912659      Adv+Drug+Deliv+Rev 2015 ; 87 (ä): 25-34
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  • DNA and RNA Derivatives to Optimize Distribution and Delivery #MMPMID25912659
  • Wickstrom E
  • Adv Drug Deliv Rev 2015[Jun]; 87 (ä): 25-34 PMID25912659show ga
  • Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).
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