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10.1016/j.addr.2015.04.005 http://scihub22266oqcxt.onion/10.1016/j.addr.2015.04.005 C4504789!4504789!25881722     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2015 ; 87 (ä): 35-45 Nephropedia Template TP {{tp|p=25881722|t=2015. Cellular Uptake and Intracellular Trafficking of Oligonucleotides |pdf=|usr=}}{{25881722}} gab.com Text Cellular Uptake and Intracellular Trafficking of Oligonucleotides JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25881722 #FOAvip Oligonucleotides manifest much promise as potential therapeutic agents. However, understanding of how oligonucleotides function within living organisms is still rather limited. A major concern in this regard is the mechanisms of cellular uptake and intracellular trafficking of both ?free? oligonucleotides and oligonucleotides associated with various polymeric or nanocarrier delivery systems. Here we review basic aspects of the mechanisms of endocytosis and intracellular trafficking and how insights from these processes can be used to understand oligonucleotide delivery. In particular we discuss opportunities for escape of oligonucleotides from endomembrane compartments and describe recent studies using small molecules to enhance oligonucleotide effects. Twit Text FOAVip Cellular Uptake and Intracellular Trafficking of Oligonucleotides ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=25881722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25881722 #FOAvip English Wikipedia <ref>{{Cite pmid|25881722}}</ref> Cellular Uptake and Intracellular Trafficking of Oligonucleotides #MMPMID25881722 Juliano R; Carver K Adv Drug Deliv Rev 2015[Jun]; 87 (ä): 35-45 PMID25881722show ga Oligonucleotides manifest much promise as potential therapeutic agents. However, understanding of how oligonucleotides function within living organisms is still rather limited. A major concern in this regard is the mechanisms of cellular uptake and intracellular trafficking of both ?free? oligonucleotides and oligonucleotides associated with various polymeric or nanocarrier delivery systems. Here we review basic aspects of the mechanisms of endocytosis and intracellular trafficking and how insights from these processes can be used to understand oligonucleotide delivery. In particular we discuss opportunities for escape of oligonucleotides from endomembrane compartments and describe recent studies using small molecules to enhance oligonucleotide effects. äCellular Uptake and Intracellular Trafficking of Oligonucleotides (epmc).pdf DeepDyve Pubget Overpricing