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10.1016/j.ccr.2012.03.003 http://scihub22266oqcxt.onion/10.1016/j.ccr.2012.03.003 C4504432!4504432!22439924     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Cell 2012 ; 21 (3): 283-96 Nephropedia Template TP {{tp|p=22439924|t=2012. Cancer stem cells: impact, heterogeneity, and uncertainty |pdf=|usr=}}{{22439924}} gab.com Text Cancer stem cells: impact, heterogeneity, and uncertainty JO: Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=22439924 #FOAvip The differentiation of tumorigenic cancer stem cells into non-tumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and non-tumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells. In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients the stem cell model may not be readily testable. Twit Text FOAVip Cancer stem cells: impact, heterogeneity, and uncertainty ????Cancer Cell http://www.kidney.de/pget.php?&tw=1&pmid=22439924 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=22439924 #FOAvip English Wikipedia <ref>{{Cite pmid|22439924}}</ref> Cancer stem cells: impact, heterogeneity, and uncertainty #MMPMID22439924 Magee JA; Piskounova E; Morrison SJ Cancer Cell 2012[Mar]; 21 (3): 283-96 PMID22439924show ga The differentiation of tumorigenic cancer stem cells into non-tumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functional differences between tumorigenic and non-tumorigenic cells influence response to therapy and prognosis. However, it remains uncertain whether the model applies to many, or few, cancers due to questions about the robustness of cancer stem cell markers and the extent to which existing assays underestimate the frequency of tumorigenic cells. In cancers with rapid genetic change, reversible changes in cell states, or biological variability among patients the stem cell model may not be readily testable. äCancer stem cells: impact, heterogeneity, and uncertainty (epmc).pdf DeepDyve Pubget Overpricing