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10.5414/CN107420

http://scihub22266oqcxt.onion/10.5414/CN107420
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C4504137!4504137!23006339
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suck abstract from ncbi


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pmid23006339      Clin+Nephrol 2013 ; 80 (6): 469-73
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  • Minimal change disease in graft versus host disease: a podocyte response to the graft? #MMPMID23006339
  • Huskey J; Rivard C; Myint H; Lucia S; Smith M; Shimada M; Ishimoto T; Araya C; Garin EH; Johnson RJ
  • Clin Nephrol 2013[Dec]; 80 (6): 469-73 PMID23006339show ga
  • Nephrotic syndrome is a rare complication of hematopoietic cell transplantation. It has been suggested that nephrotic syndrome may represent a limited form of graft-versus-host disease although the pathological link between these two entities remains unclear. In this paper, we report a case of a 61-year-old female who underwent nonmyeloablative allogenic stem cell transplantation for T-cell prolymphocytic leukemia and subsequently developed biopsy proven minimal change disease shortly after cessation of her immunosuppression therapy. Urinary CD80 was markedly elevated during active disease and disappeared following corticosteroid-induced remission. We hypothesize that alloreactive donor T cells target the kidney and induce podocyte expression of CD80 that results in proteinuria from limited ?graft versus host? disease.
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