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10.1038/srep12144 http://scihub22266oqcxt.onion/10.1038/srep12144 C4503982!4503982 !26179594     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26179594 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2015 ; 5 (ä): 12144 Nephropedia Template TP {{tp|p=26179594 |t=2015. Uric Acid Produces an Inflammatory Response through Activation of NF-?B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders |pdf=|usr=}}{{26179594 }} gab.com Text Uric Acid Produces an Inflammatory Response through Activation of NF- B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26179594 #FOAvip Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence of this, and the underlying mechanism remains unclear. Here, we showed that a high-UA diet triggered the expression of pro-inflammatory cytokines, activated the NF-?B pathway, and increased gliosis in the hypothalamus. Intracerebroventricular injection of UA induced hypothalamic inflammation and reactive gliosis, whereas these effects were markedly ameliorated by the inhibition of NF-?B. Moreover, magnetic resonance imaging confirmed that hyperuricemia in rodents and humans was associated with gliosis in the mediobasal hypothalamus. Importantly, the rats administered UA exhibited dyslipidemia and glucose intolerance, which were probably mediated by hypothalamic inflammation and hypothalamic neuroendocrine alterations. These results suggest that UA can cause hypothalamic inflammation via NF-?B signaling. Our findings provide a potential therapeutic strategy for UA-induced metabolic disorders. Twit Text FOAVip Uric Acid Produces an Inflammatory Response through Activation of NF- B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=26179594 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26179594 #FOAvip English Wikipedia <ref>{{Cite pmid|26179594 }}</ref> Uric Acid Produces an Inflammatory Response through Activation of NF-?B in the Hypothalamus: Implications for the Pathogenesis of Metabolic Disorders #MMPMID26179594 Lu W ; Xu Y ; Shao X ; Gao F ; Li Y ; Hu J ; Zuo Z ; Shao X ; Zhou L ; Zhao Y ; Cen X Sci Rep 2015[Jul]; 5 (ä): 12144 PMID26179594 show ga Epidemiological studies have shown that an elevated uric acid (UA) level predicts the development of metabolic syndrome and diabetes; however, there is no direct evidence of this, and the underlying mechanism remains unclear. Here, we showed that a high-UA diet triggered the expression of pro-inflammatory cytokines, activated the NF-?B pathway, and increased gliosis in the hypothalamus. Intracerebroventricular injection of UA induced hypothalamic inflammation and reactive gliosis, whereas these effects were markedly ameliorated by the inhibition of NF-?B. Moreover, magnetic resonance imaging confirmed that hyperuricemia in rodents and humans was associated with gliosis in the mediobasal hypothalamus. Importantly, the rats administered UA exhibited dyslipidemia and glucose intolerance, which were probably mediated by hypothalamic inflammation and hypothalamic neuroendocrine alterations. These results suggest that UA can cause hypothalamic inflammation via NF-?B signaling. Our findings provide a potential therapeutic strategy for UA-induced metabolic disorders. |*Glucose Tolerance Test [MESH] |Animals [MESH] |Biomarkers/metabolism [MESH] |Blood-Brain Barrier [MESH] |Dyslipidemias/blood/*etiology [MESH] |Gliosis/metabolism [MESH] |Humans [MESH] |Hypothalamus/*metabolism/pathology [MESH] |Inflammation/*etiology [MESH] |Magnetic Resonance Imaging [MESH] |Male [MESH] |NF-kappa B/*metabolism [MESH] |Rats [MESH] |Rats, Wistar [MESH]Uric Acid Produces an Inflammatory Response through Activation of NF-?(epmc).pdf DeepDyve Pubget Overpricing