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10.1016/j.steroids.2015.02.022

http://scihub22266oqcxt.onion/10.1016/j.steroids.2015.02.022
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C4503878!4503878!25759117
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suck abstract from ncbi


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pmid25759117      Steroids 2015 ; 99 (ä): 219-29
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  • Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon-? in primary macrophages requires endogenous 25-hydroxycholesterol synthesis #MMPMID25759117
  • Lu H; Talbot S; Robertson KA; Watterson S; Forster T; Roy D; Ghazal P
  • Steroids 2015[Jul]; 99 (ä): 219-29 PMID25759117show ga
  • ?IFN-? leads to the proteasomal degradation of HMGCR.?IFN-? and 25-HC can transcriptionally and post-translationally alter levels of HMGCR.?The reduction of HMGCR through the action of IFN-? requires the de novo synthesis of 25-HC by CH25H.
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