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10.1016/j.mcn.2014.12.009

http://scihub22266oqcxt.onion/10.1016/j.mcn.2014.12.009
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C4503822!4503822!25584786
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suck abstract from ncbi


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pmid25584786      Mol+Cell+Neurosci 2015 ; 66 (ä): 12-20
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  • Prion degradation pathways: Potential for therapeutic intervention #MMPMID25584786
  • Goold R; McKinnon C; Tabrizi SJ
  • Mol Cell Neurosci 2015[May]; 66 (ä): 12-20 PMID25584786show ga
  • Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrPC into the disease-associated form PrPSc that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating the degradation of PrPSc have shown efficacy in experimental models of prion disease. Here, we describe the cellular pathways that mediate PrPSc degradation and review possible targets for therapeutic intervention. This article is part of a Special Issue entitled ?Neuronal Protein?.
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