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10.1016/j.mcn.2015.02.016 http://scihub22266oqcxt.onion/10.1016/j.mcn.2015.02.016 C4503820!4503820 !25748120     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25748120 &cmd=llinks): Failed to open stream: HTTP request failed! 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Current and future implications of basic and translational research on amyloid-? peptide production and removal pathways |pdf=|usr=}}{{25748120 }} gab.com Text Current and future implications of basic and translational research on amyloid- peptide production and removal pathways JO: Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25748120 #FOAvip Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid ?-peptide (A?). Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of A? produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD). Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of A?. This review summarises some of the recent molecular and structural work on the role of these genes and the proteins coded by them in the biology of A?. We also briefly outline how the emerging knowledge about the pathways involved in A? generation and clearance can be potentially targeted therapeutically. This article is part of Special Issue entitled "Neuronal Protein". Twit Text FOAVip Current and future implications of basic and translational research on amyloid- peptide production and removal pathways ????Mol Cell Neurosci http://www.kidney.de/pget.php?&tw=1&pmid=25748120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25748120 #FOAvip English Wikipedia <ref>{{Cite pmid|25748120 }}</ref> Current and future implications of basic and translational research on amyloid-? peptide production and removal pathways #MMPMID25748120 Bohm C ; Chen F ; Sevalle J ; Qamar S ; Dodd R ; Li Y ; Schmitt-Ulms G ; Fraser PE ; St George-Hyslop PH Mol Cell Neurosci 2015[May]; 66 (Pt A ): 3-11 PMID25748120 show ga Inherited variants in multiple different genes are associated with increased risk for Alzheimer's disease (AD). In many of these genes, the inherited variants alter some aspect of the production or clearance of the neurotoxic amyloid ?-peptide (A?). Thus missense, splice site or duplication mutants in the presenilin 1 (PS1), presenilin 2 (PS2) or the amyloid precursor protein (APP) genes, which alter the levels or shift the balance of A? produced, are associated with rare, highly penetrant autosomal dominant forms of Familial Alzheimer's Disease (FAD). Similarly, the more prevalent late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of A?. This review summarises some of the recent molecular and structural work on the role of these genes and the proteins coded by them in the biology of A?. We also briefly outline how the emerging knowledge about the pathways involved in A? generation and clearance can be potentially targeted therapeutically. This article is part of Special Issue entitled "Neuronal Protein". |*Translational Research, Biomedical [MESH] |Alzheimer Disease/genetics/*metabolism/*therapy [MESH] |Amyloid beta-Peptides/*metabolism [MESH] |Animals [MESH] |Humans [MESH]Current and future implications of basic and translational research on(epmc).pdf DeepDyve Pubget Overpricing