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Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Nat+Chem+Biol 2009 ; 5 (12): 874-5 Nephropedia Template TP
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On the mechanism of iron sensing by IRP2: new players, new paradigms #MMPMID26190951
Takahashi-Makise N; Ward DM; Kaplan J
Nat Chem Biol 2009[Dec]; 5 (12): 874-5 PMID26190951show ga
Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.