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10.1038/nchembio.261

http://scihub22266oqcxt.onion/10.1038/nchembio.261
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C4503334!4503334!26190951
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suck abstract from ncbi


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pmid26190951      Nat+Chem+Biol 2009 ; 5 (12): 874-5
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  • On the mechanism of iron sensing by IRP2: new players, new paradigms #MMPMID26190951
  • Takahashi-Makise N; Ward DM; Kaplan J
  • Nat Chem Biol 2009[Dec]; 5 (12): 874-5 PMID26190951show ga
  • Two iron regulatory proteins (IRP1 and IRP2) regulate translation and/or stability of mRNAs encoding proteins required for iron storage, acquisition and utilization. Rather than IRP2 directly sensing iron concentrations, iron has been shown to regulate the level of the SKP1-CUL1-FBXL5 E3 ubiquitin ligase protein complex, which is responsible for IRP2 degradation.
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