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10.1146/annurev-physiol-021113-170338 http://scihub22266oqcxt.onion/10.1146/annurev-physiol-021113-170338 C4503208!4503208!24274737     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Annu+Rev+Physiol 2014 ; 76 (ä): 333-63 Nephropedia Template TP {{tp|p=24274737|t=2014. Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release |pdf=|usr=}}{{24274737}} gab.com Text Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release JO: Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24274737 #FOAvip Most neuronal communication relies upon the synchronous release of neurotransmitters, which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a presynaptic bouton. However, neurotransmitters are also released asynchronously with a longer, variable delay following an action potential or spontaneously in the absence of action potentials. A compelling body of research has identified roles and mechanisms for synchronous release, but asynchronous release and spontaneous release are less well understood. In this review, we analyze how the mechanisms of the three release modes overlap and what molecular pathways underlie asynchronous and spontaneous release. We conclude that the modes of release have key fusion processes in common but may differ in the source of and necessity for Ca2+ to trigger release and in the identity of the Ca2+ sensor for release. Twit Text FOAVip Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release ????Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=24274737 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24274737 #FOAvip English Wikipedia <ref>{{Cite pmid|24274737}}</ref> Molecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Neurotransmitter Release #MMPMID24274737 Kaeser PS; Regehr WG Annu Rev Physiol 2014[]; 76 (ä): 333-63 PMID24274737show ga Most neuronal communication relies upon the synchronous release of neurotransmitters, which occurs through synaptic vesicle exocytosis triggered by action potential invasion of a presynaptic bouton. However, neurotransmitters are also released asynchronously with a longer, variable delay following an action potential or spontaneously in the absence of action potentials. A compelling body of research has identified roles and mechanisms for synchronous release, but asynchronous release and spontaneous release are less well understood. In this review, we analyze how the mechanisms of the three release modes overlap and what molecular pathways underlie asynchronous and spontaneous release. We conclude that the modes of release have key fusion processes in common but may differ in the source of and necessity for Ca2+ to trigger release and in the identity of the Ca2+ sensor for release. äMolecular Mechanisms for Synchronous, Asynchronous, and Spontaneous Ne(epmc).pdf DeepDyve Pubget Overpricing