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ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer |pdf=|usr=}}{{26191257}} gab.com Text ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26191257 #FOAvip Background: To investigated the diagnostic and prognostic value of engulfment and cell motility (ELMO3) in non small cell lung cancer (NSCLC). Methods: The expression of ELMO3 at mRNA levels were detected using reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) in 125 NSCLC patients? tissues and adjacent tissues, as well as in the serum of 125 NSCLC patients and 89 healthy controls. Then, receiver operating characteristic curve (ROC), Kaplan-Meier and Cox regression analysis were adopted to estimate the potential diagnostic and prognostic value of ELMO3, respectively. Results: ELMO3 expression level was significantly up-regulated in NSCLC patients? tissues and serum compared with controls (P<0.001). Moreover, the expression of ELMO3 was significantly associated with tumor size (P=0.020), TNM stage (P=0.017), lymph node metastasis (PP=0.045) and distance metastasis (P=0.033). ROC showed the AUC was 0.917, and the optimal cutoff value was 0.735, providing a sensitivity of 92.8% and a specificity of 84.3%. Furthermore, Kaplan-Meier analysis indicated the high expression of ELMO3 could lead to a shorter overall survival time. In multivariate analysis, ELMO3 expression (HR=3.378, 95% CI=1.326-8.587, P=0.011) was proved to be linked with the prognosis of NSCLC and might act as an independent prognostic marker. Conclusion: The over-expression of ELMO3 was a potential diagnostic and prognostic marker for NSCLC. Twit Text FOAVip ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26191257 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26191257 #FOAvip English Wikipedia <ref>{{Cite pmid|26191257}}</ref> ELMO3 is a novel biomarker for diagnosis and prognosis of non-small cell lung cancer #MMPMID26191257 Fan W; Yang H; Xue H; Sun Y; Zhang J Int J Clin Exp Pathol 2015[]; 8 (5): 5503-8 PMID26191257show ga Background: To investigated the diagnostic and prognostic value of engulfment and cell motility (ELMO3) in non small cell lung cancer (NSCLC). Methods: The expression of ELMO3 at mRNA levels were detected using reverse transcription quantitative real-time polymerase chain reaction (qRT-PCR) in 125 NSCLC patients? tissues and adjacent tissues, as well as in the serum of 125 NSCLC patients and 89 healthy controls. Then, receiver operating characteristic curve (ROC), Kaplan-Meier and Cox regression analysis were adopted to estimate the potential diagnostic and prognostic value of ELMO3, respectively. Results: ELMO3 expression level was significantly up-regulated in NSCLC patients? tissues and serum compared with controls (P<0.001). Moreover, the expression of ELMO3 was significantly associated with tumor size (P=0.020), TNM stage (P=0.017), lymph node metastasis (PP=0.045) and distance metastasis (P=0.033). ROC showed the AUC was 0.917, and the optimal cutoff value was 0.735, providing a sensitivity of 92.8% and a specificity of 84.3%. Furthermore, Kaplan-Meier analysis indicated the high expression of ELMO3 could lead to a shorter overall survival time. In multivariate analysis, ELMO3 expression (HR=3.378, 95% CI=1.326-8.587, P=0.011) was proved to be linked with the prognosis of NSCLC and might act as an independent prognostic marker. Conclusion: The over-expression of ELMO3 was a potential diagnostic and prognostic marker for NSCLC. äELMO3 is a novel biomarker for diagnosis and prognosis of non-small ce(epmc).pdf DeepDyve Pubget Overpricing