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http://scihub22266oqcxt.onion/ C4503093!4503093 !26191221     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26191221 &cmd=llinks): Failed to open stream: HTTP request failed! 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In this study, we investigated the role of miR-221 in the development and progression of clear cell renal cell carcinoma (ccRCC). METHODS: Quantitative real-time PCR (qRT-PCR) was used to measure the expression level of miR-221 in ccRCC tissues and cell lines. Then, we investigated the role of miR-221 to determine its potential roles on renal cancer cell proliferation, migration and invasion in vitro. A luciferase reporter assay was conducted to confirm the target gene of miR-221 and the results were validated in renal cancer cells. RESULTS: In the present study, we found that miR-221 was significantly increased in ccRCC tissues and cell lines. Knocked-down expression of miR-221 remarkably inhibited cell proliferation, migration and invasion of renal cancer cells. Moreover, at the molecular level, our results suggested that TIMP2 as a direct target of miR-221 through which miR-221 promoted tumor cell proliferation, migration and invasion. CONCLUSIONS: These findings suggested that miR-221 play an oncogenic role in the renal cancer cell proliferation, migration and invasion by directly inhibiting the tumor suppressor TIMP2, indicating miR-221 act as a potential new therapeutic target for the treatment of ccRCC. Twit Text FOAVip miRNA-221 promotes proliferation, migration and invasion by targeting TIMP2 in renal cell carcinoma ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26191221 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26191221 #FOAvip English Wikipedia <ref>{{Cite pmid|26191221 }}</ref> miRNA-221 promotes proliferation, migration and invasion by targeting TIMP2 in renal cell carcinoma #MMPMID26191221 Lu GJ ; Dong YQ ; Zhang QM ; Di WY ; Jiao LY ; Gao QZ ; Zhang CG Int J Clin Exp Pathol 2015[]; 8 (5 ): 5224-9 PMID26191221 show ga INTRODUCTION: MicroRNAs (miRNAs) play important roles in tumorigenesis. In this study, we investigated the role of miR-221 in the development and progression of clear cell renal cell carcinoma (ccRCC). METHODS: Quantitative real-time PCR (qRT-PCR) was used to measure the expression level of miR-221 in ccRCC tissues and cell lines. Then, we investigated the role of miR-221 to determine its potential roles on renal cancer cell proliferation, migration and invasion in vitro. A luciferase reporter assay was conducted to confirm the target gene of miR-221 and the results were validated in renal cancer cells. RESULTS: In the present study, we found that miR-221 was significantly increased in ccRCC tissues and cell lines. Knocked-down expression of miR-221 remarkably inhibited cell proliferation, migration and invasion of renal cancer cells. Moreover, at the molecular level, our results suggested that TIMP2 as a direct target of miR-221 through which miR-221 promoted tumor cell proliferation, migration and invasion. CONCLUSIONS: These findings suggested that miR-221 play an oncogenic role in the renal cancer cell proliferation, migration and invasion by directly inhibiting the tumor suppressor TIMP2, indicating miR-221 act as a potential new therapeutic target for the treatment of ccRCC. |*Cell Movement [MESH] |*Cell Proliferation [MESH] |3' Untranslated Regions [MESH] |Binding Sites [MESH] |Carcinoma, Renal Cell/genetics/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Knockdown Techniques [MESH] |Genes, Reporter [MESH] |Humans [MESH] |Kidney Neoplasms/genetics/*metabolism/pathology [MESH] |Luciferases/genetics/metabolism [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Neoplasm Invasiveness [MESH] |Oncogenes [MESH] |RNA Interference [MESH] |Signal Transduction [MESH] |Tissue Inhibitor of Metalloproteinase-2/genetics/*metabolism [MESH]miRNA-221 promotes proliferation, migration and invasion by targeting (epmc).pdf DeepDyve Pubget Overpricing