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Cytoprotective effects of high dose of ?-galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant |pdf=|usr=}}{{26191196 }} gab.com Text Cytoprotective effects of high dose of -galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant JO: Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26191196 #FOAvip OBJECTIVE: To investigate the cytoprotective effects of high dose of ?-galactosylceramide (?-GC) on the activation-induced CD4+ T and CD8+ T cell death. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced using adoptive transfer of MOGCD4+ cells treated using ?-GC into recipient C57BL/6 mice while the MOGCD4+ cells treated using 0.5% polysorbate were set as vehicle group, based on which to investigate the effects of ?-GC on activation induced CD4+ T cell death. Additionally, an EG7 tumor-bearing mice model is established using adoptive transfer of CD8+ T cells, based on which to investigate the effect of ?-GC on the apoptosis of CD8+ T cells. RESULTS: A higher induction rate was noticed after adoptive transfer of MOGCD4+ cells treated using ?-GC together with the severity of EAE compared with the conventional methods. Longer survival duration was noted in the green fluorescent protein (GFP) labeled MOGT in the ?-GC group compared with the vehicle group (P < 0.05). Severe inflammatory cell infiltration and myelinoclasis was noted in the white matter of nervous system in the ?-GC group. In the EG7 tumor model, more adoptive CD8+ T cells were survived in ?-GC group compared with that of vehicle group. The growth of tumor mass was significantly inhibited in ?-GC group. CONCLUSIONS: high dose of ?-GC could be used as an adjuvant for inhibiting activation-induced CD4+ T and CD8+ T cell death. Our study could provide helpful information for the development of adoptive cell therapy with reduced programmed cell death. Twit Text FOAVip Cytoprotective effects of high dose of -galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant ????Int J Clin Exp Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26191196 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26191196 #FOAvip English Wikipedia <ref>{{Cite pmid|26191196 }}</ref> Cytoprotective effects of high dose of ?-galactosylceramide against activation-induced CD4+ T and CD8+ T cell death as an adjuvant #MMPMID26191196 Qian G ; Jin W ; Tian X ; Ding Z ; Shi B ; Zhang Q Int J Clin Exp Pathol 2015[]; 8 (5 ): 5026-34 PMID26191196 show ga OBJECTIVE: To investigate the cytoprotective effects of high dose of ?-galactosylceramide (?-GC) on the activation-induced CD4+ T and CD8+ T cell death. METHODS: Experimental autoimmune encephalomyelitis (EAE) was induced using adoptive transfer of MOGCD4+ cells treated using ?-GC into recipient C57BL/6 mice while the MOGCD4+ cells treated using 0.5% polysorbate were set as vehicle group, based on which to investigate the effects of ?-GC on activation induced CD4+ T cell death. Additionally, an EG7 tumor-bearing mice model is established using adoptive transfer of CD8+ T cells, based on which to investigate the effect of ?-GC on the apoptosis of CD8+ T cells. RESULTS: A higher induction rate was noticed after adoptive transfer of MOGCD4+ cells treated using ?-GC together with the severity of EAE compared with the conventional methods. Longer survival duration was noted in the green fluorescent protein (GFP) labeled MOGT in the ?-GC group compared with the vehicle group (P < 0.05). Severe inflammatory cell infiltration and myelinoclasis was noted in the white matter of nervous system in the ?-GC group. In the EG7 tumor model, more adoptive CD8+ T cells were survived in ?-GC group compared with that of vehicle group. The growth of tumor mass was significantly inhibited in ?-GC group. CONCLUSIONS: high dose of ?-GC could be used as an adjuvant for inhibiting activation-induced CD4+ T and CD8+ T cell death. Our study could provide helpful information for the development of adoptive cell therapy with reduced programmed cell death. |Adjuvants, Immunologic/*administration & dosage [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |Apoptosis/*drug effects [MESH] |CD4-Positive T-Lymphocytes/*drug effects/immunology/pathology/transplantation [MESH] |CD8-Positive T-Lymphocytes/*drug effects/immunology/pathology [MESH] |Cytoprotection [MESH] |Encephalomyelitis, Autoimmune, Experimental/*drug therapy/immunology/pathology [MESH] |Galactosylceramides/*administration & dosage [MESH] |Lymphocyte Activation/drug effects [MESH] |Lymphocytes, Tumor-Infiltrating/*drug effects/immunology/pathology [MESH] |Male [MESH] |Mice, Inbred C57BL [MESH] |Myelin-Oligodendrocyte Glycoprotein/immunology [MESH] |Spinal Cord/*drug effects/immunology/pathology [MESH]Cytoprotective effects of high dose of ?-galactosylceramide against (epmc).pdf DeepDyve Pubget Overpricing